Structural variation in ciliary bundles of the posterior semicircular canal. Quantitative anatomy and computational analysis.
Structural variation in ciliary bundles of the posterior semicircular canal. Quantitative anatomy and computational analysis.
复制标题
后半规管睫状束的结构变化。
DOI：
10.1111/j.1749-6632.1996.tb15695.x
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发表时间：
1996
影响因子：
5.2
通讯作者：
Grant,JW
中科院分区：
文献类型：
--
作者：
Peterson,EH;Cotton,JR;Grant,JW
毛细胞是机械感受器，它们的功能是将机械刺激转化为可被神经元破译的电信号。毛细胞的机械感受器是它的纤毛束，一簇修饰的微绒毛(立体纤毛)，从毛细胞的顶面延伸到迷路的腔中。睫状束的渐变偏转(通过耳石膜、杯状或内淋巴)调节毛细胞的感受器电位和前庭传入神经的放电(图1)。因此，了解控制这种渐变偏转的力学因素对于理解外周前庭信号是至关重要的。有理论和经验的理由来假设对外力的反应的偏转的大小强烈依赖于偏转的束结构(图1，阴影区域)。14因此，令人惊讶的是，前庭毛细胞中的束结构和力学之间的关系却没有得到如此严格的关注。我们在这里解决这个问题。我们在这份报告中的目标是(1)开始对羊膜前庭纤毛束结构的定量描述(注A)，强调I型和I1型受体之间可能的差异，以及(2)介绍一种计算方法来探索结构在纤毛束力学中所起的作用。
Hair cells are mechanoreceptors; their function is to transduce mechanical stimuli into electrical signals that can be decoded by neurons. The mechanoreceptive organelle of the hair cell is its ciliary bundle, a cluster of modified microvilli (stereocilia; stereovilli') that extend from the hair cell's apical surface into the cavity of the labyrinth. Graded deflection of the ciliary bundle (by otolithic membranes, cupula, or endolymph) modulates the receptor potential of the hair cell and the discharge of vestibular afferents (FIG. 1). Thus, understanding the mechanical factors governing this graded deflection is central to the understanding of peripheral vestibular signaling.There are theoretical and empirical reasons for supposing that the magnitude of bundle deflection in response to an imposed force is strongly dependent on bundle structure (FIG. 1, shaded areas). 14 Thus, it is surprising that the relation between bundle structure and mechanics in vestibular hair cells has received so little rigorous attention. We address this issue here. Our goals in this report are (1) to begin a quantitative description of vestibular ciliary bundle structure in an amniote (note A), emphasizing possible differences between type I and type I1 receptors, and (2) to introduce a computational method for exploring the role that structure plays in ciliary bundle mechanics.