The gene encoding vasoactive intestinal peptide is located on human chromosome 6p21----6qter.
The gene encoding vasoactive intestinal peptide is located on human chromosome 6p21----6qter.
复制标题
编码血管活性肠肽的基因位于人类染色体6p21----6qter上。
DOI：
10.1007/bf00273836
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发表时间：
1987
期刊：
影响因子：
5.3
通讯作者：
Huebner,K
中科院分区：
文献类型：
--
作者：
Gozes,I;Avidor,R;Yahav,Y;Katznelson,D;Croce,CM;Huebner,K
血管活性肠肽（Vasoactive intestinal peptide， VIP）是一种参与多种功能的调节性神经肽，包括血管舒张、平滑肌舒张、汗液分泌、胃肠蠕动、胰腺功能等。汗腺vip神经支配的缺陷最近被描述为囊性纤维化（CF）患者出汗的可能致病因素。为了研究有缺陷的vip基因在囊性纤维化中的可能作用，我们使用了一组啮齿动物-人类杂交细胞，保留了人类染色体的明确补体，将vip基因定位在人类染色体区域6p21→6qter。由于CF基因最近被定位到7号染色体，我们得出结论，vip基因不是该疾病的主要基因缺陷。
Vasoactive intestinal peptide (VIP) is a regulatory neuropeptide involved in a wide variety of functions, among them vasodilation, smooth muscle relaxation, sweat secretion, gastrointestinal peristalsis, and pancreatic function. A deficient VIP-innervation of sweat glands was recently described as a possible pathogenic factor in sweating of cystic fibrosis (CF) patients. To investigate a possible role for a defective VIP-gene in cystic fibrosis, we have used a panel of rodent-human hybrid cells, retaining defined complements of human chromosomes to localize the VIP-gene to the human chromosome region 6p21→6qter. As the CF gene was recently mapped to chromosome 7, we conclude that the VIP-gene is not the primary gene defect in this disease.