Autoregenerative redox nanoparticles as an antioxidant and glycation inhibitor for palliation of diabetic cataracts.
Autoregenerative redox nanoparticles as an antioxidant and glycation inhibitor for palliation of diabetic cataracts.
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DOI：
10.1039/c9nr02350j
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发表时间：
2019-07
期刊：
影响因子：
6.7
通讯作者：
Yurui Zhou;Lu Li;Shenghui Li;Shufei Li;Miao Zhao;Qinghong Zhou;Xiaoqun Gong;Jin Yang;Jin Chang
中科院分区：
文献类型：
--
作者：
Yurui Zhou;Lu Li;Shenghui Li;Shufei Li;Miao Zhao;Qinghong Zhou;Xiaoqun Gong;Jin Yang;Jin Chang
糖尿病白内障(DCs)是糖尿病最常见的眼部并发症之一，易致盲。然而，延缓和预防DC的药物有限。研究表明晶状体的氧化损伤和晶状体蛋白的非酶糖基化在DC的发病机制中起着关键作用。因此，我们开发了一种自再生氧化还原纳米粒子，即聚乙二醇聚乳酸包覆的CeO2纳米粒子(PCNPs)。我们首次发现PCNPs不仅可以作为抗氧化剂保护晶状体上皮细胞免受氧化应激的影响，而且还可以作为糖基化抑制剂有效地抑制α-晶状体蛋白的糖基化和交联，从而保持晶状体透明，缓解树突状细胞。实验结果成功地验证了PCNPs能够在眼睛内长时间工作，以减少晶状体混浊。我们期望这一策略将为DC的治疗提供有希望的潜力。
Diabetic cataracts (DCs) are one of the most common ocular complications of diabetes, and easily causes blindness among diabetics. However, there are limited drugs to delay and prevent DCs. Research studies indicate that oxidative damage of the crystalline lens and nonenzymatic glycosylation of the lens protein play a key role in the pathogenesis of DCs. Hence, we developed a kind of autoregenerative redox nanoparticle, which was CeO2 NPs coated with PEG-PLGA (PCNPs). We first found that PCNPs could work not only as an antioxidant to protect lens epithelial cells from oxidative stress based on the repetitive elimination of reactive oxygen species (ROS), but also as a glycation inhibitor effectively restraining α-crystallin glycation and crosslinking, thereby keeping the lens transparent and alleviating DCs. Experimental results successfully validated the fact that the PCNPs were able to operate in eyes for a long time to attenuate lens opacity. We expect that this strategy will provide promising potential for the treatment of DCs.