Metastasis to the sinonasal tract from sigmoid colon adenocarcinoma.
Metastasis to the sinonasal tract from sigmoid colon adenocarcinoma.
复制标题
乙状结肠腺癌转移至鼻窦。
DOI：
10.47102/annals-acadmedsg.v37n9p788
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Roszalina bte Ramli
中科院分区：
文献类型：
--
作者：
Primuharsa Putra bin Sabir Husin Athar;Norleza bte Ahmad Norhan;Lokman bin Saim;Isa bin Md Rose;Roszalina bte Ramli
介绍
从胃肠道转移到鼻窦道的腺癌是罕见的。这种病变的组织学形态与原发性窦腺癌或膀胱型腺癌（ITAC）的结肠变体难以区分。
临床表现
这是一个报告的情况下，转移腺癌的结肠直肠起源的鼻窦在一个52岁的女性谁是以前治疗的乙状结肠腺癌。对鼻窦腔手术标本的组织学研究表明，肿瘤与患者先前的原发性结肠肿瘤相同。鼻腔鼻窦肿瘤组织中癌胚抗原和细胞角蛋白20的表达明显阳性，可与转移性结肠腺癌和ITAC鉴别。
治疗/结局
患者接受姑息性放疗，但在诊断后3个月死亡。
结论
胃肠道转移性腺癌与ITAC的区别可能很困难。鉴于两者的相似性，免疫组化染色有助于鉴别。重要的是要认识到这些转移性病变的治疗主要是姑息性的。
INTRODUCTION
Metastatic adenocarcinoma from the gastrointestinal tract to the sinonasal tract is rare. The histological morphology of this lesion is indistinguishable from the colonic variant of primary sinus adenocarcinoma or intestinal-type adenocarcinoma (ITAC).
CLINICAL PICTURE
This is a report of a case of metastatic adenocarcinoma of colorectal origin to the paranasal sinuses in a 52-year-old female who was previously treated for adenocarcinoma of the sigmoid colon. A histologic study of the surgical specimen from the sinonasal cavity demonstrated a tumour identical to the patient's prior primary tumour of the colon. The sinonasal neoplastic tissue showed marked positivity for carcinoembryonic antigen and expressed cytokeratin 20, which differentiates metastatic colonic adenocarcinoma from ITAC.
TREATMENT/OUTCOME
The patient received palliative radiation but died 3 months after the diagnosis.
CONCLUSION
Distinguishing metastatic adenocarcinoma from gastrointestinal tract from ITAC can be difficult. In view of the resemblance, immunohistochemical staining can help in differentiating them. It is important to recognise these as metastatic lesions as the treatment is mainly palliative.