Usefulness of vasopressin administered with epinephrine during out-of-hospital cardiac arrest
Usefulness of vasopressin administered with epinephrine during out-of-hospital cardiac arrest
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DOI：
10.1016/j.amjcard.2006.06.022
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发表时间：
2006-11-15
影响因子：
2.8
通讯作者：
Kelly, Lori J.
中科院分区：
文献类型：
--
作者：
Callaway, Clifton W.;Hostler, David;Kelly, Lori J.
已经建议在心肺复苏期间施用加压素，并且先前的临床试验已经表明加压素与肾上腺素一起施用时最有效。在非创伤性、院外心脏骤停心肺复苏期间接受静脉注射肾上腺素≥ 1剂的成人受试者（n = 325）被随机分配至40 IU血管加压素组（n = 167）或安慰剂组（n = 158），肾上腺素首次给药后尽快接受。加压素组和安慰剂组的脉搏恢复率相似（31%比30%），急诊室的脉搏出现率也相似（19%比23%）。没有亚组出现差异性影响，并没有加压素的影响是明显的调整后，其他临床变量。安慰剂组19例受试者和加压素组27例受试者在研究药物给药后由医生给予额外的开放标签加压素。如果这些受试者被排除或被分配到实际接受的药物组，结果相似。入院受试者的生存时间在两组之间没有差异。总之，血管加压素与肾上腺素合用不能增加自主循环的恢复率。(c)2006年爱思唯尔公司All rights reserved.
Vasopressin administration has been suggested during cardiopulmonary resuscitation, and a previous clinical trial has suggested that vasopressin is most effective when administered with epinephrine. Adult subjects (n = 325) who received >= 1 dose of intravenous epinephrine during cardiopulmonary resuscitation for nontraumatic, out-of-hospital cardiac arrest were randomly assigned to receive 40 IU of vasopressin (n = 167) or placebo (n = 158) as soon as possible after the first dose of epinephrine. The rate of return of pulses was similar between the vasopressin and placebo groups (31% vs 30%), as was the presence of pulses at the emergency department (19% vs 23%). No subgroup appeared to be differentially affected, and no effect of vasopressin was evident after adjustment for other clinical variables. Additional open-label vasopressin was administered by a physician after the study drug for 19 subjects in the placebo group and 27 subjects in the vasopressin group. Results were similar if these subjects were excluded or were assigned to an actual drug received. Survival duration for subjects admitted to the hospital did not differ between groups. In conclusion, vasopressin administered with epinephrine does not increase the rate of return of spontaneous circulation. (c) 2006 Elsevier Inc. All rights reserved.