SELENIUM IN CARDIOLOGY AND ANGIOLOGY
SELENIUM IN CARDIOLOGY AND ANGIOLOGY
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DOI：
10.1007/bf02990134
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发表时间：
1988-01-01
影响因子：
3.9
通讯作者：
DUCK, HJ
中科院分区：
文献类型：
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作者：
KOEHLER, H;PETERS, HJ;DUCK, HJ
在因室间支前结扎而梗塞的猪心脏中，研究了亚硒酸钠形式的硒对中枢血流动力学状况和冠状动脉流量的影响。按每公斤体重 1-3 毫克的浓度输注亚硒酸钠溶液可改善梗塞猪的存活率。亚硒酸盐的短期和长期保护作用都可以得到证明。亚硒酸钠给药抑制细胞膜的电脆弱性，特别是缺血边界区心室晚电位的发生，具有潜在的治疗重要性。心率增加、冠状动脉扩张和外周血管舒张表明冠状动脉血液循环也得到改善。因此，脉动冠状动脉血流发生改变，增加了梗塞心脏的总灌注。对人类受试者的初步观察表明，缺硒是缺血性和动脉硬化性心脏病发病机制中的一个因素。 54 名临床诊断为急性心肌梗死的住院患者中，血清硒水平为 670±266 nmol/L，而 93 名健康对照者的血清硒水平为 981±209 nmol/L。 32例全身动脉硬化患者的血清硒水平为375±85 nmol/L，64例腿部动脉硬化闭塞性疾病患者的血清硒水平为366±85 nmol/L。健康受试者的血清硒水平存在年龄和性别依赖性。在男性中，41-50 岁年龄组的硒浓度达到最高水平 1083 nmol/L。同年龄组女性血清硒水平为1385 nmol/L。有证据表明，硒可以防止脂质过氧化对心脏细胞膜的氧化损伤。
The effect selenium in the form of sodium selenite on central hemodynamic conditions and coronary artery flow was studied in pig hearts infarcted by a ligature of the ramus interventricularis anterior. Infusions of sodium selenite solutions at levels of 1–3 mg/kg body wt improved the survival of infarcted pigs. Both short-term and long-term protective effects of selenite could be demonstrated. It is of potential therapeutic importance that sodium selenite administration suppresses the electrical vulnerability of the cell membrane, notably the occurrence of ventricular late potentials in the ischemic border zone. Coronary blood circulation, as evidenced by an increase of heart rate and coronary artery dilatation and peripheral vasodilatation was also improved. The pulsatile coronary blood flow thus is altered, increasing total perfusion of the infarcted heart.Initial observations with human subjects suggest that selenium deficiency is a factor in the pathogenesis of ischemic and arteriosclerotic heart disease. In 54 hospitalized patients with clinical diagnosis of acute myocardial infarction, serum selenium levels were 670±266 nmol/L, as compared to 981±209 nmol/L in 93 healthy controls. In 32 patients with general arteriosclerosis, the serum Se level was 375±85 nmol/L, in 64 patients with arteriosclerotic occlusional disease in the leg region, 366±85 nmol/L, respectively.Serum selenium levels of healthy subjects were found to be age-and sex dependent. In men, the selenium concentrations reached maximum levels of 1083 nmol/L in the 41–50 y age group. In women in the same age group, the serum Se level was 1385 nmol/L. Evidence is presented to suggest that selenium is preventing oxidative damage of heart cell membranes by lipid peroxidation.