EVIDENCE THAT CHLAMYDIA-PNEUMONIAE CAUSES PNEUMONIA AND BRONCHITIS
EVIDENCE THAT CHLAMYDIA-PNEUMONIAE CAUSES PNEUMONIA AND BRONCHITIS
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DOI：
10.1093/infdis/168.5.1231
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发表时间：
1993-11-01
影响因子：
6.4
通讯作者：
ALTMAN, J
中科院分区：
文献类型：
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作者：
GRAYSTON, JT;ALDOUS, MB;ALTMAN, J
流行病往往为获得微生物与疾病的病原学联系的证据提供了机会。肺炎衣原体是一种新发现的微生物，其与疾病的关系尚不完全清楚。对1990年11月至1991年2月在华盛顿大学学生中暴发的肺炎衣原体感染进行了研究。在54名患有急性呼吸道疾病的学生中，用血清学方法鉴定出12例TWAR感染。从12株细菌中分离出7株，对分离阴性的2株进行了聚合酶链式反应(PCR)鉴定。在1991年培养的42名血清阴性患者或51名无呼吸道疾病的对照学生患者中均未发现这种细菌。12例肺炎衣原体感染患者均未发现肺炎支原体或呼吸道病毒感染。在4个月的暴发期间，肺炎病例总数有所增加。这些发现为肺炎衣原体肺炎和支气管炎的病因学联系提供了证据。
An epidemic often provides an opportunity to obtain evidence of the etiologic association of a microorganism with disease. Chlamydia pneumoniae TWAR is a newly recognized organism whose relationship to disease is not completely understood. An outbreak of C pneumoniae infections from November 1990 to February 1991 was studied in University of Washington students. Twelve TWAR infections were identified serologically in 54 students with acute respiratory disease. The organism was isolated from 7 of the 12 and identified by the polymerase chain reaction (PCR) in 2 that were isolation-negative. The organism was not found in any of the 42 serologically negative patients or in 51 control student patients without respiratory illness cultured in 1991. There was no evidence of infection with Mycoplasma pneumoniae or respiratory viruses in the 12 patients with C. pneumoniae infection. During the 4-month outbreak, there was an increase in total pneumonia cases. These findings provide evidence for an etiologic association of C. pneumoniae with pneumonia and bronchitis.