Intrinsically Antibacterial Poly(ionic liquid) Membranes: The Synergistic Effect of Anions
Intrinsically Antibacterial Poly(ionic liquid) Membranes: The Synergistic Effect of Anions
复制标题
本质抗菌聚（离子液体）膜：阴离子的协同效应
DOI：
10.1021/acsmacrolett.5b00609
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发表时间：
2015-10-01
影响因子：
7.015
通讯作者：
Yan, Feng
中科院分区：
文献类型：
--
作者：
Guo, Jiangna;Xu, Qiming;Yan, Feng
开发具有内在抗菌活性的材料引起了人们极大的兴趣。在此，我们报告的独立和强大的聚（离子液体）（Pit）膜的合成具有高的抗菌活性的离子液体单体的原位光交联，然后通过与氨基酸（L-脯氨酸（Pro）或L-色氨酸（Trp））的阴离子交换。所得到的具有优异耐用性的PIL基膜对革兰氏阴性大肠杆菌（E.大肠杆菌）和革兰氏阳性金黄色葡萄球菌（S.金黄色葡萄球菌），并且对人红细胞和皮肤成纤维细胞没有显著的溶血和细胞毒性，以及对牛血清白蛋白的低吸附。合成的PIL-Trp膜由于咪唑阳离子和Trp（-）阴离子的协同属性而表现出最高的抗菌效率。此外，所有基于PIL的膜都表现出长期抗菌稳定性，这证明了局部应用的临床可行性。
The development of materials with intrinsically antimicrobial activities has attracted great interest. Herein, we report the synthesis of free-standing and robust poly(ionic liquid) (Pit) membranes with high antibacterial activities by in situ photo-cross-linking of an ionic liquid monomer and followed by anion-exchange with an amino acid (L-proline (Pro) or L-tryptophan (Trp)). The resultant PIL-based membranes with excellent robustness exhibit high antimicrobial properties against both Gram-negative Escherichia coli (E. coli) and Gram-positive Staphylococcus aureus (S. aureus) and present no significant hemolysis and cytotoxicity toward human red blood and skin fibroblast cells, as well as low adsorption of bovine serum albumin. The synthesized PIL-Trp membranes exhibit the highest antibacterial efficiency due to the synergistic attributes of both imidazolium cation and Trp(-) anion. Furthermore, all the PIL-based membranes exhibit long-term antibacterial stability, which demonstrates clinical feasibility in topical applications.