CLINICAL PHARMACOLOGY OF CEFADROXIL IN INFANTS AND CHILDREN
CLINICAL PHARMACOLOGY OF CEFADROXIL IN INFANTS AND CHILDREN
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DOI：
10.1128/aac.13.5.845
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发表时间：
1978-01-01
影响因子：
4.9
通讯作者：
THOMAS, ML
中科院分区：
文献类型：
--
作者：
GINSBURG, CM;MCCRACKEN, GH;THOMAS, ML
The pharmacokinetics of cefadroxil suspension was studied in 30 children, 13 mo. to 12 yr of age (mean age, 5.7 yr). Average peak concentrations in serum of 11-14 .mu.g/ml and of 7-10 .mu.g/ml after 15- and 10-mg/kg doses, respectively, were not substantially affected by the feeding status. The serum half-life values were 1.3-1.5 h. Cefadroxil was detected in saliva of all children 2 h after 15-mg/kg doses: the levels ranged from 0.17-2.6 .mu.g/ml (mean, 0.46 .mu.g/ml). The average concentrations in urine were 1700-2620 .mu.g/ml at 0-2 and 2-4 h, respectively, after 15-mg/kg doses. In a randomized controlled study of 50 children with impetigo, cefadroxil was as effective as penicillin G in curing existing lesions and in preventing development of new lesions. Cefadroxil may be useful for therapy of mucocutaneous and urinary tract infections in infants and children.
