Vitamin D status and 5-year changes in periodontal disease measures among postmenopausal women: the Buffalo OsteoPerio Study.
Vitamin D status and 5-year changes in periodontal disease measures among postmenopausal women: the Buffalo OsteoPerio Study.
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DOI：
10.1902/jop.2014.130686
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发表时间：
2014-10
影响因子：
4.3
通讯作者：
Wactawski-Wende J
中科院分区：
文献类型：
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作者：
Millen AE;Andrews CA;LaMonte MJ;Hovey KM;Swanson M;Genco RJ;Wactawski-Wende J
假设维生素D通过其免疫调节特性及其在维持全身钙浓度中的作用来预防牙周病进展。我们在一项妇女健康倡议观察性研究的辅助研究中，调查了655名绝经后妇女的血浆25（OH）D（1997 - 2000年收集）与牙周病指标从基线（1997-2000年）到随访（2002-2005年）的5年变化之间的关系。在628名随访时也有25（OH）D测量的妇女中进行了探索性分析。牙周病的五年变化的四个连续措施进行了评估，使用牙槽嵴高度（ACH），临床附着水平（CAL），探测袋深度（PD），和牙龈出血的评估后的网站的百分比。使用线性回归估计β系数（β）、标准误（SE）和对应于牙周病变化的p值（ACH、CAL或PD变化1 mm，或牙龈流血的部位百分比变化1个单位），25（OH）D差异为10 nmol/L。模型调整了年龄，教育，牙科就诊频率，吸烟，糖尿病状况，目前影响骨骼健康的药物，牙周病的基线测量，体重指数和娱乐性体力活动。基线25（OH）D与牙周病指标变化之间无统计学显著相关性，总体或25（OH）D浓度稳定的女性子集（n=442）（25（OH）D从基线到随访变化小于± 20 nmol/L的女性）。在按基线牙周病状态分层的分析中，结果也没有显著差异。基线25（OH）D和随后的5年牙周病指标变化之间没有相关性。维生素D状态可能不会影响牙周病的进展。需要更多的研究来证实这些结果。在我们对绝经后妇女的前瞻性研究中，使用25-羟基维生素D浓度评估的基线维生素D状态与牙周病的5年进展（定义为牙槽骨变化、临床附着、探诊袋深度或牙龈出血）无关。
Vitamin D is hypothesized to prevent periodontal disease progression through its immune modulating properties and its role in maintaining systemic calcium concentrations. We investigated associations between plasma 25(OH)D (collected 1997–2000) and the five-year change in periodontal disease measures from baseline (1997–2000) to follow-up (2002–2005) among 655 postmenopausal women in a Women’s Health Initiative Observational Study ancillary study. Exploratory analyses were conducted in 628 women who also had 25(OH)D measures at follow-up. Four continuous measures of five-year change in periodontal disease were assessed using alveolar crestal height (ACH), clinical attachment level (CAL), probing pocket depth (PD), and percent of gingival sites that bled upon assessment. Linear regression was used to estimate beta-coefficients (β), standard errors (SE), and p-values corresponding to change in periodontal disease (either a 1 mm change in ACH, CAL or PD, or 1 unit change in the percent of gingival sites that bled) for a 10 nmol/L difference in 25(OH)D. Models were adjusted for age, education, dental visit frequency, smoking, diabetes status, current medications affecting bone health, baseline measures of periodontal disease, body mass index, and recreational physical activity. No statistically significant associations were observed between baseline 25(OH)D and change in periodontal disease measures, overall or in a subset (n=442) of women with stable 25(OH)D concentrations (women whose 25(OH)D changed less than ± 20 nmol/L from baseline to follow-up). Results also did not vary significantly in analyses that were stratified by baseline periodontal disease status. No association between baseline 25(OH)D and the subsequent five-year change in periodontal disease measures was observed. Vitamin D status may not influence periodontal disease progression. More studies are needed to confirm these results. In our prospective study in postmenopausal women, baseline vitamin D status, assessed using 25-hydroxyvitamin D concentrations, was not associated with the five-year progression of periodontal disease defined as changes in alveolar bone, clinical attachment, probing pocket depth, or gingival bleeding.