BDNF Val66Met modifies the risk of childhood trauma on obsessive-compulsive disorder
BDNF Val66Met modifies the risk of childhood trauma on obsessive-compulsive disorder
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DOI：
10.1016/j.jpsychires.2013.08.012
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发表时间：
2013-12-01
影响因子：
4.8
通讯作者：
Stein, Dan J.
中科院分区：
文献类型：
--
作者：
Hemmings, Sian Megan Joanna;Lochner, Christine;Stein, Dan J.
童年创伤与后来的精神病理，包括强迫症（OCD）的发展有关。虽然有证据表明遗传和环境因素参与了强迫症的病因，但很少有人关注基因和环境之间的相互作用。本研究的目的是研究童年创伤与强迫症患者BDNF Val66Met变异之间的基因-环境相互作用。采用儿童创伤问卷（CTQ）对134名强迫症患者和188名对照者进行儿童创伤评估。采用线性回归模型进行统计分析。通过在模型中包括基因型和CTQ评分作为相互作用项来估计基因环境相互作用。通过将年龄、性别、CTQ最小化拒绝得分和家庭语言作为协变量纳入逻辑回归模型，对所有分析进行了调整。童年创伤，特别是情感虐待和忽视，显著增加了患强迫症的几率（p < 0.001）。虽然BDNF Val66Met与强迫症的发生没有明显的相关性，但相互作用分析表明，BDNF met等位基因与儿童时期的情绪虐待相互作用会显著增加强迫症的风险，并呈剂量依赖性（p = 0.024）。据我们所知，这是第一个研究强迫症中基因和环境相互作用的研究之一，研究结果表明，在未来的研究中，整理遗传和环境变量的重要性。(C) 2013 Elsevier Ltd.版权所有。
Childhood trauma has been linked to the development of later psychopathology, including obsessive-compulsive disorder (OCD). Although evidence exists to suggest that genetic and environmental factors are involved in the aetiology of OCD, little attention has been paid to the interactions that exist between genes and environment The aim of this study was to investigate gene-by-environment interactions between childhood trauma and the BDNF Val66Met variant in patients with OCD.Childhood trauma was assessed in 134 OCD patients and 188 controls using the Childhood Trauma Questionnaire (CTQ). Linear regression models were used for statistical analyses. Gene environment interactions were estimated by including a combined genotype and CTQ score in the models as interaction terms. All analyses were adjusted for age, gender, CTQ minimisation-denial score and home language by including them in the logistic regression models as covariates.Childhood trauma, specifically emotional abuse and neglect, increased the odds of having OCD significantly (p < 0.001). Although no significant association was observed between BDNF Val66Met and the development of OCD, interaction analysis indicated that the BDNF Met-allele interacted with childhood emotional abuse to increase the risk of OCD significantly in a dose-dependent manner (p = 0.024). To our knowledge, this is one of the first studies to investigate gene environment interactions in OCD, and the findings indicate the importance of collating genetic and environmental variables in future studies. (C) 2013 Elsevier Ltd. All rights reserved.