An international invasive meningococcal disease outbreak due to a novel and rapidly expanding serogroup W strain, Scotland and Sweden, July to August 2015
An international invasive meningococcal disease outbreak due to a novel and rapidly expanding serogroup W strain, Scotland and Sweden, July to August 2015
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DOI：
10.2807/1560-7917.es.2016.21.45.30395
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发表时间：
2016-11-10
期刊：
影响因子：
19
通讯作者：
Borrow, R.
中科院分区：
文献类型：
--
作者：
Lucidarme, J.;Scott, K. J.;Borrow, R.
2015年第23届世界童军大露营在日本举行，来自162个国家的33，000多名童军参加。在会议结束后的9天内，苏格兰和瑞典的侦察员及其密切接触者中发生了6例实验室确认的侵袭性血清型W脑膜炎球菌病。通过常规分型，负责的分离株彼此相同，并且已知（4个分离株）属于ST-11克隆复合体（cc 11），其与大爆发和高病死率相关。最近的研究表明，需要高分辨率的基因组分型方案分配血清群W cc 11分离株几个不同的菌株在过去的二十年中在全球范围内流通。在这里，我们使用这些方案来确认与大露营相关的病例构成了真正的疫情，这是由于一种新的快速扩张的菌株，该菌株是最近在南美和英国扩张的菌株的后代。我们还确定了定义新菌株的遗传差异，包括4个点突变和3个假定的重组事件，分别涉及17个，6个和2个基因的水平交换。这些变化的显著结果是抗原性转变和转录调节因子的破坏。
The 23rd World Scout Jamboree in 2015 took place in Japan and included over 33,000 scouts from 162 countries. Within nine days of the meeting ending, six cases of laboratory-confirmed invasive serogroup W meningococcal disease occurred among scouts and their close contacts in Scotland and Sweden. The isolates responsible were identical to one-another by routine typing and, where known (4 isolates), belonged to the ST-11 clonal complex (cc11) which is associated with large outbreaks and high case fatality rates. Recent studies have demonstrated the need for high-resolution genomic typing schemes to assign serogroup W cc11 isolates to several distinct strains circulating globally over the past two decades. Here we used such schemes to confirm that the Jamboree-associated cases constituted a genuine outbreak and that this was due to a novel and rapidly expanding strain descended from the strain that has recently expanded in South America and the United Kingdom. We also identify the genetic differences that define the novel strain including four point mutations and three putative recombination events involving the horizontal exchange of 17, six and two genes, respectively. Noteworthy outcomes of these changes were antigenic shifts and the disruption of a transcriptional regulator.