Corticosteroid-Binding Globulin (CBG) of Man and Other Species
Corticosteroid-Binding Globulin (CBG) of Man and Other Species
复制标题
人类和其他物种的皮质类固醇结合球蛋白 (CBG)
DOI：
--
复制
发表时间：
1971
期刊：
影响因子：
--
通讯作者：
U. Westphal
中科院分区：
文献类型：
--
作者：
U. Westphal
在1956年，Daughthorn（1956 a）和Bush（1957）分别通过平衡透析技术证明了人血浆中存在一种特异性蛋白质，该蛋白质能够以非常高的亲和力结合皮质类固醇，但结合能力较低。这些性质清楚地将相互作用蛋白与白蛋白区分开来;它被称为皮质类固醇结合球蛋白（CBG）。同时，Sandberg、Slaunwhite和Antoniades（1957）报告了人血浆和血浆蛋白组分中获得的类固醇结合数据，这些数据不能通过白蛋白结合来解释; Sandberg和Slaunwhite，1958; Slaunwhite和Sandberg，1959）将其解释为表明存在一种对皮质类固醇激素具有高结合亲和力的特殊蛋白，称为转皮质素。Sandberg等人（1966）叙述了运皮质素这一证明的背景。厄普顿和邦迪（1958）在超滤研究中证实，少量皮质醇与除白蛋白以外的血浆蛋白强结合。Desgrez（1967）总结了导致CBG被认识的一些观察结果。
In 1956, Daughaday (1956 a) and Bush (1957) independently demonstrated by equilibrium dialysis techniques the presence in human plasma of a specific protein capable of binding corticosteroids with very high affinity but low capacity. These qualities clearly distinguished the interacting protein from albumin; it was termed the corticosteroid-binding globulin (CBG). At the same time, Sandberg, Slaunwhite and Antoniades (1957) reported steroid binding data obtained with human plasma and plasma protein fractions which could not be accounted for by albumin binding; they were interpreted Sandberg and Slaunwhite, 1958; Slaunwhite and Sandberg, 1959) as indicating the existence of a special protein of high binding affinity for corticosteroid hormones which was named transcortin. The background to this demonstration of transcortin has been recounted by Sandberg et al. (1966). Upton and Bondy (1958) confirmed in ultrafiltration studies the strong binding of small amounts of cortisol to a plasma protein other than albumin. Desgrez (1967) has summarized some of the observations that led to the recognition of CBG.