Vitamin E Conditionally Inhibits Atherosclerosis in ApoE Knockout Mice by Anti-oxidation and Regulation of Vasculature Gene Expressions
Vitamin E Conditionally Inhibits Atherosclerosis in ApoE Knockout Mice by Anti-oxidation and Regulation of Vasculature Gene Expressions
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维生素 E 通过抗氧化和调节脉管系统基因表达有条件地抑制 ApoE 基因敲除小鼠的动脉粥样硬化
DOI：
10.1007/s11745-014-3962-z
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发表时间：
2014-11
期刊：
影响因子：
1.9
通讯作者：
Wang Hongxin
中科院分区：
文献类型：
--
作者：
Tang F;Lu meili;Zhang suping;Mei men;Wang T;Liu P;Wang Hongxin
Lipid deposition in artery walls is implied in the pathogenesis of atherosclerosis and imbalance between uptake and efflux of cholesterol favors the deposition. We investigated the effect of vitamin E with the same dose and duration on the different stages of atherosclerosis in Apolipoprotein E knockout (ApoE KO) mice and explored the potential mechanisms. The results showed that the ApoE KO mouse spontaneously develops atherosclerosis in an age‐dependent manner from 14 to 46 weeks on the regular chow. Vitamin E (100 mg/kg) supplementation to ApoE KO mice at 6, 14, and 22 weeks for 8 weeks significantly reduced the atherosclerotic lesion area by 41, 29 and 19 % respectively compared to the age‐matched control mice; however had no significant effect on the lesion when given at 30 and 38 weeks. In addition, vitamin E supplemented at the ages from 6 to 30 weeks decreased the contents of serum oxLDL and TBARS without affecting the TC and TAG contents in serum and liver. Furthermore, vitamin E supplemented at 6, 14 and 22 weeks down‐regulated vasculature mRNA expressions of scavenger receptor CD36 and up‐regulated mRNA expressions of PPARγ, LXRα and ABCA1 which are involved in reverse cholesterol transportation; however had no significant effects on these genes when given at 30 and 38 weeks. In conclusion, vitamin E with same dose and duration inhibits the early but not advanced atherosclerotic lesion in ApoE KO mice by anti‐oxidation and regulation of mRNA expression of genes involved in cholesterol uptake and efflux, which favors the improvement of atherosclerosis.
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影响因子：
1.9
作者：
Kotosai, Mari;Shimada, Sachiko;Kanda, Mai;Matsuda, Namiko;Sekido, Keiko;Shimizu, Yoshibumi;Tokumura, Akira;Nakamura, Toshiyuki;Murota, Kaeko;Kawai, Yoshichika;Terao, Junji
通讯作者：
Terao, Junji
影响因子：
20.1
作者：
't Hoen, PAC;Van der Lans, CAC;Twisk, J
通讯作者：
Twisk, J
影响因子：
6.5
作者：
D. Schwenke;L. Rudel;M. Sorci-Thomas;Michael J. Thomas
通讯作者：
D. Schwenke;L. Rudel;M. Sorci-Thomas;Michael J. Thomas
DOI：
10.1093/jn/121.1.65
发表时间：
1991
期刊：
The Journal of nutrition
影响因子：
--
作者：
D. Li;Y. M. Wang;R. Nath;S. Mistry;K. Randerath
通讯作者：
D. Li;Y. M. Wang;R. Nath;S. Mistry;K. Randerath
影响因子：
16
作者：
A. Chawla;W. Boisvert;Chih‐Hao Lee;B. Laffitte;Y. Barak;S. Joseph;D. Liao;Laszlo Nagy;Peter A.
通讯作者：
A. Chawla;W. Boisvert;Chih‐Hao Lee;B. Laffitte;Y. Barak;S. Joseph;D. Liao;Laszlo Nagy;Peter A.