INDUCTION, REPAIR AND BIOLOGICAL RELEVANCE OF RADIATION-INDUCED DNA LESIONS IN EUKARYOTIC CELLS
INDUCTION, REPAIR AND BIOLOGICAL RELEVANCE OF RADIATION-INDUCED DNA LESIONS IN EUKARYOTIC CELLS
复制标题
DOI：
10.1007/bf01210408
复制
发表时间：
1990-01-01
影响因子：
1.7
通讯作者：
FRANKENBERGSCHWAGER, M
中科院分区：
文献类型：
--
作者：
FRANKENBERGSCHWAGER, M
本报告总结了五种辐射引起的 DNA 损伤的诱导、修复和生物学相关性的数据，各个实验室已在真核细胞中对其进行了修复动力学研究。这些损伤是：DNA-蛋白质交联、碱基损伤、单链断裂、双链断裂和大块损伤（纳米范围内的簇状碱基损伤）。描述了各种因素对这些损伤的诱导和修复的影响，例如缺氧/缺氧、所用辐射的线性能量转移、培养介质、细胞周期阶段、硫醇含量、高温。还包括辐射敏感细胞系。
This report summarizes data on the induction, repair and biological relevance of five types of radiation-induced DNA lesions for which repair kinetic studies have been performed in eukaryotic cells by various laboratories. These lesions are: DNA-protein crosslinks, base damage, single-strand breaks, double-strand breaks and bulky lesions (clustered base damage in the nm-range). The influence of various factors, such as oxia/anoxia, linear energy transfer of the radiation used, incubation medium, cell cycle stage, thiol content, hyperthermia, on the induction and repair of these lesions is described. Radiation-sensitive cell lines are also included.