Tracheal blood flow and luminal clearance of 99mTc-DTPA in sheep.
Tracheal blood flow and luminal clearance of 99mTc-DTPA in sheep.
复制标题
绵羊气管血流量和 99mTc-DTPA 的管腔清除率。
DOI：
10.1152/jappl.1992.73.4.1273
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发表时间：
1992
影响因子：
3.3
通讯作者：
J. Widdicombe
中科院分区：
文献类型：
--
作者：
Z. Hanafi;D. Corfield;S. Webber;J. Widdicombe
测定绵羊体内气管血流和99mtc标记的二乙烯三胺五乙酸（DTPA）清除率。分离气管动脉并灌注。用含有99mTc-DTPA的Krebs-Henseleit溶液填充一段气管腔，并在插管气管静脉血液中测量放射性。恒压输注甲胆碱（n = 5）、沙丁胺醇（n = 6）和组胺（n = 5）使动脉流入（分别为+250 +/- 73.0、+74.2 +/- 22.9、+68.9 +/- 39.2% (SE)）和静脉流出（+49.5 +/- 13.8、+11.6 +/- 4.5、+6.2 +/- 13.9%）增加，99mTc-DTPA输出（-36.8 +/- 8.4、-20.4 +/- 6.2、-58.1 +/- 11.7%）和浓度（-53.9 +/- 10.1、-27.3 +/- 7.5、-49.3 +/- 14.4%）降低。苯肾上腺素（n = 9）降低了动脉流入（-49.4 +/- 10.0%）和静脉流出（-4.1 +/- 5.9%），但增加了99mTc-DTPA输出（+74.6 +/- 44.2%）和浓度（+94.4 +/- 56.6%）。气管动脉初始恒流量灌注后改变流量，流量增加50% (n = 5)，灌注压升高（+35.9 +/- 2.2%），静脉流出量升高（+10.5 +/- 3.8%），99mTc-DTPA输出量降低（-24.4 +/- 7.8%），浓度降低（-30.4 +/- 8.8%）。血流减少50% （n = 3）和100% (n = 10)，灌注压（分别为-34.2 +/- 4.2、-80.1 +/- 3.5%）和静脉流出（分别为-11.0 +/- 4.8、-29.7 +/- 7.2%）降低，99mTc-DTPA输出（+45.9 +/- 27.5、+167.4 +/- 70.4%）和浓度（+64.7 +/- 26.7、+305.7 +/- 110.2%）增加。（摘要删节250字）
Tracheal blood flow and 99mTc-labeled diethylenetriamine pentaacetic acid (DTPA) clearance were measured in the sheep trachea in vivo. The tracheal arteries were isolated and perfused. An isolated segment of tracheal lumen was filled with Krebs-Henseleit solution containing 99mTc-DTPA, and radioactivity was measured in blood from a catheterized tracheal vein. Infusions at constant pressure of methacholine (n = 5), albuterol (n = 6), and histamine (n = 5) increased arterial inflow [+250 +/- 73.0, +74.2 +/- 22.9, +68.9 +/- 39.2% (SE), respectively] and venous outflow (+49.5 +/- 13.8, +11.6 +/- 4.5, +6.2 +/- 13.9%) but decreased 99mTc-DTPA output (-36.8 +/- 8.4, -20.4 +/- 6.2, -58.1 +/- 11.7%) and concentration (-53.9 +/- 10.1, -27.3 +/- 7.5, -49.3 +/- 14.4%). Phenylephrine (n = 9) decreased arterial inflow (-49.4 +/- 10.0%) and venous outflow (-4.1 +/- 5.9%) but increased 99mTc-DTPA output (+74.6 +/- 44.2%) and concentration (+94.4 +/- 56.6%). When the tracheal arteries were initially perfused at constant flow and the flow rate was then changed, 50% increases in flow (n = 5) increased perfusion pressure (+35.9 +/- 2.2%) and venous outflow (+10.5 +/- 3.8%) but decreased 99mTc-DTPA output (-24.4 +/- 7.8%) and concentration (-30.4 +/- 8.8%). Decreases in flow of 50% (n = 3) and 100% (n = 10) decreased perfusion pressure (-34.2 +/- 4.2, -80.1 +/- 3.5%, respectively) and venous outflow (-11.0 +/- 4.8, -29.7 +/- 7.2%) but increased 99mTc-DTPA output (+45.9 +/- 27.5, +167.4 +/- 70.4%) and concentration (+64.7 +/- 26.7, +305.7 +/- 110.2%).(ABSTRACT TRUNCATED AT 250 WORDS)