Incorporation of tumor shape into an assessment of spatial heterogeneity for human sarcomas imaged with FDG-PET
Incorporation of tumor shape into an assessment of spatial heterogeneity for human sarcomas imaged with FDG-PET
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DOI：
10.1093/biostatistics/kxi010
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发表时间：
2005-04-01
期刊：
影响因子：
2.1
通讯作者：
Eary, J
中科院分区：
文献类型：
--
作者：
O'Sullivan, F;Roy, S;Eary, J
我们一直在探索技术评估氟脱氧葡萄糖（FDG）的利用特点，在人类肉瘤测量正电子发射断层扫描。在以前的工作中，开发了一种基于评估肿瘤区域内FDG利用分布与单峰椭圆形轮廓空间模式的偏差的空间异质性测量。这一指标被证明是至死亡时间的一个强有力的预后指标。目前的工作探讨了一个更一般的措施，异质性，其中包括肿瘤边界信息。该方法依赖于肿瘤边界表面的非参数表示的使用。一组179例肉瘤患者的后续评估与此技术。结果进行了分析，以获得经验的洞察力的因素解释椭圆形的异质性。就患者生存率而言，纳入更复杂的空间异质性测量显示了预测风险的一些潜在改善。进一步的数据将使我们能够获得一个更清晰的经验了解的作用，表面信息的测量肿瘤异质性。
We have been exploring techniques for evaluation of fluoro-deoxyglucose (FDG) utilization characteristics in human sarcomas measured with positron emission tomography. In previous work, a measure of spatial heterogeneity based on evaluating the deviation of the FDG utilization distribution within the tumor region from a unimodal elliptically contoured spatial pattern was developed. This measure was shown to be a strong prognostic indicator of time to death. The present work explores a more general measure of heterogeneity which incorporates tumor boundary information. The approach relies on the use of a non-parametric representation for the tumor boundary surface. A set of 179 sarcoma patients with follow-up are evaluated with this technique. The results are analyzed to obtain empirical insight into the factors explaining elliptical heterogeneity. In terms of patient survival, the incorporation of the more sophisticated measure of spatial heterogeneity shows some potential improvement in the prediction risk. Further data will enable us to obtain a clearer empirical understanding of the role of the surface information in the measurement of tumor heterogeneity.