Remote Control of Cellular Functions: The Role of Smart Nanomaterials in the Medicine of the Future
Remote Control of Cellular Functions: The Role of Smart Nanomaterials in the Medicine of the Future
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DOI：
10.1002/adhm.201700002
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发表时间：
2017-05-10
影响因子：
10
通讯作者：
Ciofani, Gianni
中科院分区：
文献类型：
--
作者：
Genchi, Giada Graziana;Marino, Attilio;Ciofani, Gianni
通过智能纳米材料远程控制细胞功能代表了一种生物操纵方法，在许多医学领域具有前所未有的潜在应用，从癌症治疗到组织工程。通过积极响应外部刺激，智能纳米材料充当真实的纳米换能器，能够介导和/或将不同形式的能量转化为物理和化学线索，促进特定的细胞行为。本报告描述了那些主要为生物现象的“无线”控制铺平道路的纳米材料类别，重点讨论了一些接近临床实践的例子。特别是，磁场，光照射，超声波和pH值将作为手段来操纵细胞的命运，由于一些智能纳米粒子的特殊物理/化学性质，从而提供了“nanorobots”接近理查德·费曼的有远见的想法现实的例子。
The remote control of cellular functions through smart nanomaterials represents a biomanipulation approach with unprecedented potential applications in many fields of medicine, ranging from cancer therapy to tissue engineering. By actively responding to external stimuli, smart nanomaterials act as real nanotransducers able to mediate and/or convert different forms of energy into both physical and chemical cues, fostering specific cell behaviors. This report describes those classes of nanomaterials that have mostly paved the way to a "wireless" control of biological phenomena, focusing the discussion on some examples close to the clinical practice. In particular, magnetic fields, light irradiation, ultrasound, and pH will be presented as means to manipulate the cellular fate, due to the peculiar physical/chemical properties of some smart nanoparticles, thus providing realistic examples of "nanorobots" approaching the visionary ideas of Richard Feynman.