CONTINUOUS ENDURANCE-TYPE EXERCISE TRAINING DOES NOT MODULATE SATELLITE CELL CONTENT IN OBESE TYPE 2 DIABETES PATIENTS
CONTINUOUS ENDURANCE-TYPE EXERCISE TRAINING DOES NOT MODULATE SATELLITE CELL CONTENT IN OBESE TYPE 2 DIABETES PATIENTS
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DOI：
10.1002/mus.21891
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发表时间：
2011-03-01
期刊：
影响因子：
3.4
通讯作者：
van Loon, Luc J. C.
中科院分区：
文献类型：
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作者：
Snijders, Tim;Verdijk, Lex B.;van Loon, Luc J. C.
耐力型运动训练是2型糖尿病治疗的基石。然而，长时间的连续性，间歇性运动对肌纤维特性的影响仍然是模棱两可的。15名肥胖男性2型糖尿病患者（61 +/-6岁）参加了为期6个月的连续、间歇性运动计划。在干预前、干预后2个月和干预后6个月收集肌肉活检。肌纤维类型的具体组成，大小，卫星细胞（SC）和肌钙蛋白含量进行了测定，免疫组化。虽然持续的耐力型运动训练降低了总体重和减少了脂肪量，但没有观察到腿部瘦体重的变化。在基线时，SC含量在II型肌纤维中显著低于I型肌纤维。运动训练后SC含量无明显变化。持续的耐力型运动训练降低脂肪量，但它不会增加腿部瘦体重和/或调节2型糖尿病患者的肌纤维特征。肌肉神经43：393 - 401，2011
Endurance-type exercise training represents a cornerstone in type 2 diabetes treatment.. However, the effects of prolonged continuous, endurance-type exercise on muscle fiber characteristics remain equivocal. Fifteen obese male type 2 diabetes patients (61 +/- 6 years) participated in a 6-month continuous, endurance-type exercise program. Muscle biopsies were collected before, and after 2 and 6 months of intervention. Muscle fiber type-specific composition, size, and satellite cell (SC) and myonuclear content were determined by immunohistochemistry. Although continuous endurance-type exercise training lowered total body weight and reduced fat mass, no changes were observed in leg lean mass. At baseline, SC content was significantly lower in type II compared with type I muscle fibers. No change in SC content was observed after exercise training. Continuous endurance-type exercise training lowers fat mass, but it does not increase leg lean mass and/or modulate muscle fiber characteristics in type 2 diabetes patients. Muscle Nerve 43: 393-401, 2011