The expression of neurogenic loci in imaginal epidermal cells of Drosophila melanogaster.
The expression of neurogenic loci in imaginal epidermal cells of Drosophila melanogaster.
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DOI：
10.3109/01677068409107094
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发表时间：
1984-12-01
影响因子：
1.9
通讯作者：
Campos-Ortega, J A
中科院分区：
文献类型：
--
作者：
Dietrich, U;Campos-Ortega, J A
黑腹果蝇的6个合子表达基因N、bib、mam、neu、d1和E(Spl)参与了外胚层细胞作为神经母细胞的定位。我们研究了这6个基因座上不同突变等位基因诱导的表型，以评估这些基因在早期神经发生以外的功能中的可能意义。纯合时，除bib外，任何这些突变都会以不同的方式影响刚毛和复眼的发育。根据所使用的等位基因，这些疾病的范围从细胞死亡到额外的刷毛的产生，以及眼球图案中的几个缺陷。相比之下，BIB纯合子细胞的克隆表现出野生型表型。关于神经发生的遗传控制假说，讨论了在神经发生基因表达上发现的差异。
Six zygotically expressed genomic loci of Drosophila melanogaster, N, bib, mam, neu, Dl and E (spl), have previously been found to be involved in the commitment of ectodermal cells as neuroblasts. We have studied phenotypes induced by various mutant alleles at these 6 loci in imaginal epidermal cells, in order to assess possible implications of the genes in functions other than early neurogenesis. When homozygous, any of these mutations except bib affected the development of bristles and compound eye in various ways. These range from cell death to the production of additional bristles and several defects in ommatidial patterning, depending on the allele used. In contrast clones of bib homozygous cells exhibited wild-type phenotypes. The differences found in the expression of the neurogenic genes are discussed with respect to a hypothesis on the genetic control of neurogenesis.