Man-ping regions within cosmopolitan inversion In(3R)Payne associated with natural variation in body size in Drosophila melanogaster
Man-ping regions within cosmopolitan inversion In(3R)Payne associated with natural variation in body size in Drosophila melanogaster
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DOI：
10.1534/genetics.107.074336
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发表时间：
2007-09-01
期刊：
影响因子：
3.3
通讯作者：
Partridge, Linda
中科院分区：
文献类型：
--
作者：
Kennington, W. Jason;Hoffmann, Ary A.;Partridge, Linda
已经报道了几种生物体中倒位基因型与数量性状之间的关联，但很少有人对控制这些性状变异的倒位内的区域进行定位。在此，我们提出了一种关联作图技术，以识别果蝇 In(3R)Payne 世界性倒位中控制翅膀大小变化的基因组区域。之前的研究表明，这种倒位强烈影响翅膀大小的变化，而翅膀大小是与体型高度相关的性状。我们发现，在考虑倒位本身的附加效应后，In(3R)Payne 内两个不同区域的三个等位基因对翅膀大小具有显着的附加效应。还有一些等位基因对翅膀大小具有显着的基因型与倒位相互作用的影响。没有一个等位基因对发育时间产生显着的累加效应，这表明不同的基因控制这些性状，因此它们的临床模式是独立出现的。 In(3R)Payne 中存在多个控制大小的区域，这与倒位在群体中持续存在的观点是一致的，因为它们包含多组局部适应的等位基因，但需要做更多的工作来测试它们是否确实是相互适应的。
Associations between genotypes for inversions and quantitative traits have been reported in several organisms, but little has been done to localize regions within inversions controlling variation in these traits. Here, we rise an association mapping technique to identify genomic regions controlling variation in wing size within the cosmopolitan inversion In(3R)Payne in Drosophila melanogaster Previous studies have shown that this inversion strongly influences variation in wing size, a trait highly correlated with body size. We found three alleles from two separate regions within In(3R)Payne with significant additive effects on wing size after the additional effect of the inversion itself had been taken into account. There were also several alleles with significant genotype-by-inversion interaction effects on wing size. None of the alleles tested bad a significant additive effect on development time, suggesting different genes control these traits and that clinal patterns in them have therefore arisen independently. The presence of multiple regions within In(3R)Payne controlling size is consistent with the idea that inversions persist in populations because they contain multiple sets of locally adapted alleles, but more work needs to be done to test if they are indeed coadapted.