Phenotype-genotype correlations of facial width and height proportions in patients with Class II malocclusion.
Phenotype-genotype correlations of facial width and height proportions in patients with Class II malocclusion.
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DOI：
10.1111/ocr.12084
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发表时间：
2015-04
影响因子：
3.1
通讯作者：
Southard TE
中科院分区：
文献类型：
--
作者：
Moreno Uribe LM;Ray A;Blanchette DR;Dawson DV;Southard TE
To characterize soft tissue facial height and width variation in Class II malocclusion and test for correlations with genes HMGA2, AJUBA and ADK. Nine facial proportions were estimated from 2D frontal repose photographs of 330 Caucasian adults with Class II malocclusion. After adjustments for age and gender, the facial proportions were submitted to a principal component analyses (PCA). The most meaningful phenotypic variations were correlated with SNPS rs7924176 (ADK), rs17101923 (HMGA2), and rs997154 (AJUBA) genotyped in 106 individuals. PCA resulted in 4 principal components (PCs) which explained 75% of total variation. PC1 captured variation in the intercanthus distance and explained 28% of total variation. PC2 explained 21% of the variations in facial taper and facial index. PC3 explained 14% and reflected variations in the vertical dimension of the lower face. PC4 explained 12% and captured variations in distance between the eyes, width of the commissures, and the length of the superior aspect of the lower face height, corresponding to the vertical dimension of the philtrum of the upper lip. A suggestive association (p<0.05) was observed between PC4 and rs997154 corroborating the role of AJUBA in variation of facial dimensions. 2D frontal photographs can be used to derive quantitative measures of soft tissue phenotypes that are of clinical relevance. The methods described are suitable for discovery and replication of associations between genotypes and malocclusion phenotypes.
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DOI：
10.1016/j.cub.2010.02.035
发表时间：
2010-04-13
期刊：
Current biology : CB
影响因子：
--
作者：
Das Thakur M;Feng Y;Jagannathan R;Seppa MJ;Skeath JB;Longmore GD
通讯作者：
Longmore GD
影响因子：
2.9
作者：
Claudino D;Traebert J
通讯作者：
Traebert J
影响因子：
2.4
作者：
Miller, Steven F.;Weinberg, Seth M.;Uribe, Lina M. Moreno
通讯作者：
Uribe, Lina M. Moreno
影响因子：
3.1
作者：
Franchi, L;Baccetti, T
通讯作者：
Baccetti, T
影响因子：
4.4
作者：
Coussens, AK;van Daal, A
通讯作者：
van Daal, A