Maternal behavior in male rats: Effects of medial preoptic area lesions and presence of maternal aggression
Maternal behavior in male rats: Effects of medial preoptic area lesions and presence of maternal aggression
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DOI：
10.1006/hbeh.1996.0025
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发表时间：
1996-09-01
影响因子：
3.5
通讯作者：
Poole, J
中科院分区：
文献类型：
--
作者：
Rosenblatt, JS;Hazelwood, S;Poole, J
雄性大鼠在青春期前和成年期表现出母性行为，但尚未研究雄性对刺激雌性母性攻击（母性行为激发后）的激素的神经机制和反应能力。在实验1中，雄性暴露于幼鼠，以刺激母性行为（致敏）后，无论是射频病变的MPOA或假病变与非激活电极，穿透MPOA。非手术雄性动物作为对照组。病变男性组表现出严重的缺陷，在所有组成部分的母亲的行为相比，后两组，没有表现出行为缺陷。与假手术2雌性（电极降低至MPOA以上，无电流）和非手术对照雌性相比，病变组和假手术1病变（由电极产生，无电流引入MPOA）雌性也显示出严重的母性行为缺陷。在实验2中，在去势雄性动物中，延长雌二醇（E（2））、孕酮（P）治疗，然后注射20 μ g/kg或100 μ g/kg苯甲酸雌二醇（EB）或油，对刺激短潜伏期母性行为有效，主要是在100 μ g/kg EB组。这一组的男性也表现出高水平的母性攻击，这与他们对母性行为的宽容呈负相关。当母性行为建立时，所有组都表现出母性攻击。结果表明，MPOA介导的母性行为在男性中，因为它在女性中;母性攻击在男性伴随着母性行为的刺激，可能是由相同的激素刺激。(C)出版社：Academic Press，Inc.
Male rats exhibit maternal behavior prepuberally and in adulthood, but the neural mechanisms and the ability of males to respond to hormones that stimulate maternal aggression (following arousal of maternal behavior) in females have not been studied. In Experiment 1, males were exposed to pups to stimulate maternal behavior (sensitization) after either radiofrequency lesions of the MPOA or sham lesions with nonactivated electrodes that penetrated the MPOA. Nonsurgical males served as a CONTROL group. The LESION male group showed severe deficits in all components of maternal behavior compared to the latter two groups that showed no behavioral deficits. Females in the LESION group and those given SHAM 1 lesions (produced by electrodes without current introduced into the MPOA) also showed severe deficits in maternal behavior compared to SHAM 2 females (electrode lowered to above the MPOA without current) and nonsurgical CONTROL females. In Experiment 2, prolonged estradiol (E(2)), progesterone (P) treatment followed by an injection of either 20 mu g or 100 mu g/kg estradiol benzoate (EB) or oil in castrated males was effective in stimulating short-latency maternal behavior, mainly in the 100 mu g/kg EB group. Males of this group also showed a high level of maternal aggression that was inversely correlated with their latencies for maternal behavior. AII groups showed maternal aggression when maternal behavior was established. The results indicate the MPOA mediates maternal behavior in males as it does in females; maternal aggression in males accompanies the stimulation of maternal behavior and may be stimulated by the same hormones. (C) 1996 Academic Press, Inc.