Pregnancy-specific association of vitamin D deficiency and bacterial vaginosis
Pregnancy-specific association of vitamin D deficiency and bacterial vaginosis
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DOI：
10.1016/j.ajog.2010.08.013
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发表时间：
2011-01-01
影响因子：
9.8
通讯作者：
Ratner, Adam J.
中科院分区：
文献类型：
--
作者：
Hensel, Katherine J.;Randis, Tara M.;Ratner, Adam J.
目的：最近的数据表明维生素D缺乏症（VDD）与妊娠期细菌性阴道病（BV）有关。我们假设VDD是BV在nonpregnancy women.Study设计：使用国家健康和营养调查数据，我们进行了多变量logistic回归分析分层pregnancy.RESULTS：VDD与BV仅在孕妇（调整优势比[AOR]，2.87; 95%置信区间[CI]，1.13-7.28）。在非怀孕妇女中，冲洗（AOR，1.72; 95% CI，1.25-2.37），吸烟（AOR，1.66; 95% CI，1.23-2.24），黑人（AOR，2.41; 95%CI，1.67-3.47）与BV相关;口服避孕药的使用与BV呈负相关（AOR，0.60; 95%CI，0.40-0.90）。VDD调节吸烟和BV之间的关联在非妊娠women.CONCLUSION：BV的危险因素不同的妊娠状态。VDD是孕妇BV的一个可改变的危险因素;妊娠期补充维生素D预防或辅助治疗BV是必要的。
OBJECTIVE: Recent data suggest vitamin D deficiency (VDD) is associated with bacterial vaginosis (BV) during pregnancy. We hypothesized that VDD is a risk factor for BV in nonpregnant women.STUDY DESIGN: Using National Health and Nutrition Examination Survey data, we conducted multivariable logistic regression analyses stratified by pregnancy.RESULTS: VDD was associated with BV only in pregnant women (adjusted odds ratio [AOR], 2.87; 95% confidence interval [CI], 1.13-7.28). Among nonpregnant women, douching (AOR, 1.72; 95% CI, 1.25-2.37), smoking (AOR, 1.66; 95% CI, 1.23-2.24), and black race (AOR, 2.41; 95% CI, 1.67-3.47) were associated with BV; oral contraceptive use was inversely associated with BV (AOR, 0.60; 95% CI, 0.40-0.90). VDD moderated the association between smoking and BV in nonpregnant women.CONCLUSION: Risk factors for BV differ by pregnancy status. VDD was a modifiable risk factor for BV among pregnant women; evaluation of vitamin D supplementation for prevention or adjunct therapy of BV in pregnancy is warranted.