Bladder Cancer in the Genomic Era
Bladder Cancer in the Genomic Era
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DOI：
10.5858/arpa.2018-0329-ra
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发表时间：
2019-06-01
影响因子：
4.6
通讯作者：
Czerniak, Bogdan
中科院分区：
文献类型：
--
作者：
Guo, Charles C.;Czerniak, Bogdan
背景-膀胱癌是一种表现出广泛的临床和病理特征的异质性疾病。传统上，膀胱癌的分类是基于免疫组织化学的形态学评估。然而，最近的基因组研究显示，膀胱癌的DNA和RNA的不同变化可能是其不同的临床病理特征的基础，导致了对这种常见人类癌症的新的分子分类。目的：更新膀胱癌基因组特征的最新进展，这可能有助于深入了解膀胱癌起源的分子机制、双轨致癌途径、内在分子亚型和组织变异的发展。-来自PubMed Search的同行评议文献和作者自己的研究。结论-膀胱癌可能来自不同的尿前体细胞，通过乳头/腔和非乳头/基底轨道。膀胱癌的固有分子亚型称为腔型和基底型，表现出不同的表达特征、临床病理特征和对标准化疗的敏感性。膀胱癌的基因组特征为理解这种复杂疾病的生物学本质提供了新的见解，这可能导致更有效的治疗。
Context.-Bladder cancer is a heterogeneous disease that exhibits a wide spectrum of clinical and pathologic features. The classification of bladder cancer has been traditionally based on morphologic assessment with the aid of immunohistochemistry. However, recent genomic studies have revealed that distinct alterations of DNA and RNA in bladder cancer may underlie its diverse clinicopathologic features, leading to a novel molecular classification of this common human cancer.Objective.-To update recent developments in genomic characterization of bladder cancer, which may shed insights on the molecular mechanisms underlying the origin of bladder cancer, dual-track oncogenic pathways, intrinsic molecular subtyping, and development of histologic variants.Data Sources.-Peer-reviewed literature retrieved from PubMed search and authors' own research.Conclusions.-Bladder cancer is likely to arise from different uroprogenitor cells through papillary/luminal and nonpapillary/basal tracks. The intrinsic molecular subtypes of bladder cancer referred to as luminal and basal exhibit distinct expression signatures, clinicopathologic features, and sensitivities to standard chemotherapy. Genomic characterization of bladder cancer provides new insights to understanding the biological nature of this complex disease, which may lead to more effective treatment.