Voxel-wise analysis of diffusion tensor imaging for clinical outcome of cochlear implantation: retrospective study.
Voxel-wise analysis of diffusion tensor imaging for clinical outcome of cochlear implantation: retrospective study.
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DOI：
10.3342/ceo.2012.5.s1.s37
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发表时间：
2012-04
影响因子：
3
通讯作者：
Lee SH
中科院分区：
文献类型：
--
作者：
Chang Y;Lee HR;Paik JS;Lee KY;Lee SH
回顾性评价采用独立于研究者的体素分析，在手术效果良好和较差的人工耳蜗植入（CI）患者中，弥散张量成像（DTI）指标分数各向异性（FA）可能存在的差异。18例重度感音神经性听力损失患者（男11例，女7例，平均年龄5.9岁）采用3.0 Tesla磁共振扫描仪进行DTI扫描。18例患者中，10例听力表现（CAP）分类评分大于6分的患者归为预后良好组，8例CAP评分低于6分的患者归为预后不良组。扩散张量标量测量从每个受试者逐体素的张量特征值计算，并对整个大脑的FA值的每个体素进行好坏结果受试者的双样本t检验评估，体素强度阈值P<0.0005（未校正），连续簇大小为64体素。使用基于兴趣区域的分析来测量FA的个体值，并与CAP分数、开放句子和开放单词分数进行相关性分析。使用SPM体素分析的双样本t检验评估发现，与结果较差的受试者相比，结果良好的受试者在几个大脑区域（包括布洛卡区、胼胝体膝和听道）的FA值显着高于结果较差的受试者。FA和CAP评分、开放句子和开放单词评分的相关分析显示，内侧膝状核、布洛卡区、胼胝体膝和听道的相关程度较高。研究者独立的基于体素的DTI图像分析显示，结果良好的受试者在与语言和听觉功能相关的大脑区域显示出更好的神经完整性，这表明保护这些大脑区域的微观结构完整性是重要的。术前功能成像可能对CI有帮助。
To evaluate retrospectively, the possible difference in diffusion tensor imaging (DTI) metric of fractional anisotropy (FA) between good and poor surgical outcome cochlear implantation (CI) patients using investigator-independent voxel-wise analysis. Eighteen patients (11 males, 7 females; mean age, 5.9 years) with profound sensorineural hearing loss underwent DTI scans using a 3.0 Tesla magnetic resonance scanner. Among the 18 patients, 10 patients with categories of auditory performance (CAP) score over 6 were classified into the good outcome group and 8 patients with CAP score below 6 were classified into the poor outcome group. The diffusion tensor scalar measure was calculated from the eigenvalues of the tensor on a voxel-by-voxel basis from each subject and two-sample t-test evaluation between good and poor outcome subjects were performed for each voxel of FA values, across the entire brain, with a voxel-wise intensity threshold of P<0.0005 (uncorrected) and a contiguous cluster size of 64 voxels. Individual values of FA were measured by using the region-of-interest based analysis for correlation analysis with CAP scores, open sentence and open word scores. Two-sample t-test evaluation using SPM voxel-wise analysis found significantly higher FA values at the several brain areas including Broca's area, genu of the corpus callosum, and auditory tract in good outcome subjects compared to poor outcome subjects. Correlation analyses between FA and CAP scores, open sentence and open word scores revealed strong correlations at medial geniculate nucleus, Broca's area, genu of the corpus callosum and auditory tract. Investigator-independent voxel-based analysis of DTI image demonstrated that good outcome subjects showed better neural integrity at brain areas associated with language and auditory functions, suggesting that the conservation of microstructural integrity of these brain areas is important. Preoperative functional imaging may be helpful for CI.