Calcium carbonate microcapsules encapsulating biomacromolecules
Calcium carbonate microcapsules encapsulating biomacromolecules
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DOI：
10.1016/j.cej.2007.09.010
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发表时间：
2008-03-15
影响因子：
15.1
通讯作者：
Nakahara, Yoshiko
中科院分区：
文献类型：
--
作者：
Fujiwara, Masahiro;Shiokawa, Kurni;Nakahara, Yoshiko
本文报道了碳酸钙微胶囊的制备及生物大分子如牛血清白蛋白（BSA）和双链DNA直接包埋在碳酸钙微胶囊中的研究。将碳酸盐和钙盐分别溶解于内层水相和外层水相中，通过界面反应法有效地制备了空心碳酸钙微胶囊。对于微胶囊结构的制备，球文石作为碳酸钙晶体的亚稳相的形成是一个重要因素。将生物大分子溶解于（NH_4）（_2）CO_3水溶液中作为内水相，成功地将这些生物大分子包封在CaCO_3微胶囊中。微胶囊中所含的生物大分子在微胶囊颗粒不破裂的情况下几乎不被消除。生物大分子的这些特性可用于各种生物相关材料。(C)2007 Elsevier B.V.保留所有权利。
This paper reports the preparation of CaCO3 microcapsules and the direct encapsulation of biomacromolecules such as bovine serum albumin (BSA) and duplex DNA into the CaCO3 microcapsules. Vacant CaCO3 microcapsules were effectively obtained by interfacial reaction method using carbonate salts and calcium salts, which were dissolved in inner water phase or outer one, respectively. For the fabrication of microcapsule structure, the formation of vaterite as a metastable phase of calcium carbonate crystal was an important factor. When some biomacromolecules were dissolved in the aqueous solution of (NH4)(2)CO3 as the inner water phase, these macromolecules were successfully encapsulated into CaCO3 microcapsules. Biomacromolecules included in the microcapsules scarcely eliminated without the fracture of the microcapsule particles. These properties of encapsulated biomacromolecules might be utilized in various bio-related materials. (C) 2007 Elsevier B.V. All rights reserved.