Plateletcrit: A sensitive biomarker for evaluating disease activity in Crohn's disease with low hs-CRP
Plateletcrit: A sensitive biomarker for evaluating disease activity in Crohn's disease with low hs-CRP
复制标题
血小板比容：一种敏感的生物标志物，用于评估低 hs-CRP 克罗恩病的疾病活动度。
DOI：
10.1111/1751-2980.12225
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发表时间：
2015-03-01
影响因子：
3.5
通讯作者：
Liang, Zhe Zhao
中科院分区：
文献类型：
--
作者：
Tang, Jian;Gao, Xiang;Liang, Zhe Zhao
本研究旨在探讨血小板指数是否可以作为活动性克罗恩病（CD）的非侵入性生物标志物。方法共130例CD患者和130名年龄和性别匹配的健康志愿者回顾性参加了这项研究。CD患者进一步分为活动性疾病（克罗恩病活动指数[CDAI]>150）和缓解期患者。检测血小板计数（PLT）、平均血小板体积（MPV）、血小板分布宽度（PDW）、血小板大细胞比率（P-LCR）和血小板压积（PCT）。结果CD活动期患者PLT、PCT水平明显高于健康对照组和缓解期患者，而PLCR、PDW水平明显低于缓解期患者。PLT、PDW、P-LCR、PCT与CDAI显著相关（P
ObjectiveThis study aimed to investigate whether PLT indices could act as non-invasive biomarkers for active Crohn's disease (CD).MethodsAltogether 130 CD patients and 130 age- and gender-matched healthy volunteers were retrospectively enrolled in the study. CD patients were further divided into patients with active disease (Crohn's disease activity index [CDAI]>150) and in remission. PLT indices including PLT count, mean platelet volume (MPV), platelet distribution width (PDW), platelet large cell ratio (P-LCR) and plateletcrit (PCT) were detected. High-sensitivity C-reactive protein (hs-CRP) and erythrocyte sedimentation rate (ESR) levels were also determined.ResultsIn active CD, PLT and PCT levels were notably higher but P-LCR and PDW levels were lower than those in healthy controls and patients in remission. PLT, PDW, P-LCR and PCT were significantly correlated with CDAI (P