Two rheologically different gastric mucus secretions with different putative functions.
Two rheologically different gastric mucus secretions with different putative functions.
复制标题
两种流变学不同的胃粘液分泌物，具有不同的假定功能。
DOI：
10.1016/j.bbagen.2004.06.007
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
J. Pearson
中科院分区：
文献类型：
--
作者：
Catherine Taylor;A. Allen;P. Dettmar;J. Pearson
Previous work has shown the presence of different mucin gene products and glycosylated species in gastric mucus secretions, however, the functional relevance of these differences is unclear. This study aimed to investigate rheologically, differences in the gel behaviour within gastric mucus samples using a pig model. Rheological measurements were made on a Bohlin CVO50 rheometer. Mucins were characterised by antigenicity, lectin reactivity and proteolytic fragmentation patterns. Two distinct mucus gel secretions, one compliant with and the other resistant to shear stress, were removed from the gastric mucosa. The two gels had different rheological behaviour profiles and exhibited structural differences in their constituent mucins. The shear-compliant mucus was located superficially to the adherent shear-resistant mucus layer and was shown not to be a proteolytic product of the latter. This study has demonstrated that there are two rheologically distinct mucus gel secretions with structural/compositional differences in the stomach. Rheological properties suggest that the adherent, shear-resistant gel could provide the mucus barrier in vivo while the shear-compliant gel could act primarily as a lubricant.
编码猪胃粘蛋白的 cDNA 克隆的分离和表征。
DOI：
10.1042/bj3080089
发表时间：
1995
期刊：
The Biochemical journal
影响因子：
--
作者：
Turner,BS;Bhaskar,KR;Hadzopoulou-Cladaras,M;Specian,RD;LaMont,JT
通讯作者：
LaMont,JT