The Use of Lentinan for Treating Gastric Cancer
The Use of Lentinan for Treating Gastric Cancer
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DOI：
10.2174/1871520611313050002
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发表时间：
2013-06-01
影响因子：
2.8
通讯作者：
Ando, Takafumi
中科院分区：
文献类型：
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作者：
Ina, Kenji;Kataoka, Takae;Ando, Takafumi
在中国和日本，含有真菌β-葡聚糖的天然化合物被用来改善一般健康已有数千年的历史。香菇多糖是β-(1，3)-葡聚糖的主链，含有β-(1，6)支链，是从香菇中提纯的活性成分之一，在日本已被批准作为生物反应调节剂用于治疗胃癌。尽管最近在化疗药物方面取得了进展，但无法切除或复发的胃癌仍然是一种无法治愈的疾病，生存率远远不能令人满意。最近的临床研究表明，与单纯化疗相比，使用香菇多糖进行化学免疫治疗可以延长进展期胃癌患者的生存时间。此外，曲妥珠单抗，一种针对HER2/neu生长因子受体的抗体，已被用于与细胞毒性化疗药物联合治疗胃癌。香菇多糖可能通过抗体依赖性细胞毒和补体依赖性细胞毒的机制与抗癌单抗协同激活补体系统。由于对香菇多糖的生物学活性有更深入的了解，因此我们可以更有效地利用香菇多糖来治疗胃癌。本文就β-葡聚糖的免疫学作用、香菇多糖的一种可能的作用方式以及香菇多糖的临床应用和潜在用途作一综述。
Natural compounds containing fungal beta-glucans have been used to improve general health for thousands of years in China and Japan. Lentinan, the backbone of beta-(1, 3)-glucan with beta-(1, 6) branches, is one of the active ingredients purified from Shiitake mushrooms and has been approved as a biological response modifier for the treatment of gastric cancer in Japan. Despite recent advances in chemotherapeutic agents, unresectable or recurrent gastric cancer remains an incurable disease, with survival rates being far from satisfactory. Recent clinical studies have shown that chemo-immunotherapy using lentinan prolongs the survival of patients with advanced gastric cancer, as compared to chemotherapy alone. In addition, trastuzumab, an antibody against HER2/neu growth factor receptor, has been used for the treatment of gastric cancer in combination with cytotoxic chemotherapeutic agents. Lentinan may exert a synergistic action with anti-cancer monoclonal antibodies to activate complement systems through the mechanism of antibody-dependent cellular cytotoxicity and complement dependent cytotoxicity. Because a better understanding of its biological activities should enable us to use lentinan more efficiently in the treatment of gastric cancer, immunological effects provided by beta-glucans, a possible mode of action of lentinan, and its clinical application including future potential uses are discussed in the present review.