Highly sensitive MRI chemical exchange saturation transfer agents using liposomes
Highly sensitive MRI chemical exchange saturation transfer agents using liposomes
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DOI：
10.1002/anie.200501473
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发表时间：
2005-01-01
影响因子：
16.6
通讯作者：
Terreno, E
中科院分区：
文献类型：
--
作者：
Aime, S;Delli Castelli, D;Terreno, E
化学交换饱和转移(CEST)试剂代表了一类具有巨大潜力的新兴磁共振成像(MRI)造影剂。它们通过化学交换介导的饱和转移降低水质子的信号强度，从而起到负离子的作用。这里报道的结果表明，LIPOCEST试剂代表了一类创新的磁共振成像探针，具有出色的灵敏度(按脂质体计算)。此外，由于脂质体中水的化学位移取决于位移试剂的性质和浓度以及脂质体膜的通透性，因此可以很容易地接触到许多不同吸收频率的LIPOCEST试剂。这种方法将允许通过特定地照射同一样品中存在的各种LIPOCEST试剂来进行的实验的戏剧性扩展。
Chemical exchange saturation transfer (CEST) agents represent an emerging class of magnetic resonance imaging (MRI) contrast media that has huge potential. They act as negative agents by reducing the signal intensity of the water protons through a saturation transfer mediated by chemical exchange. The results reported here show that LIPOCEST agents represent an innovative class of MR imaging probes of outstanding sensitivity (per liposome). Moreover, as the chemical shift of water entrapped within the liposomes depends upon the nature and concentration of the shift reagent as well as on the permeability of the liposome membrane, one may envisage facile access to a number of LIPOCESTagents with different absorption frequencies. This approach will allow a dramatic extension of the experiments that can be carried out by having the possibility of irradiating the various LIPOCEST agents present in the same sample specifically.