Targeting Tumor Microenvironment: The Key Role of Immune System
Targeting Tumor Microenvironment: The Key Role of Immune System
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DOI：
10.5681/bi.2012.001
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发表时间：
2012-01-01
期刊：
影响因子：
2.6
通讯作者：
Barar, Jaleh
中科院分区：
文献类型：
--
作者：
Barar, Jaleh
近年来，对肿瘤进展和侵袭的大量研究使人们认识到肿瘤微环境的关键作用。当前的癌症治疗时代是基于这样一种概念，即简单地针对精确的机制来杀死或抑制恶性细胞的生长和扩张。临床数据与体外结果明显相关，强调癌症环境对疾病进展的直接影响。这为通过以组合方式靶向肿瘤的癌细胞和非肿瘤成分来推进癌症治疗提供了机会。这一量身定制的策略需要对肿瘤环境的生物因素与候选药物的相应药理之间的串扰有深刻的了解。肿瘤附近对癌细胞如何生长和侵袭周围组织至关重要。肿瘤微环境似乎是一个“合作”，包括恶性肿瘤细胞、血管、免疫/炎症因子和细胞外基质。作为一个长期存在的困境，免疫系统在这种鸡舍的存在和发展中起着直接的作用，这一点已经得到了充分的证明。在某些情况下，免疫细胞，如肿瘤相关巨噬细胞(TAMs)渗透到肿瘤中，而不是对抗癌细胞，支持它们生长。作为一个重要的事实，这种肿瘤的复杂性不应该被认为是理所当然的，因为它可以在癌症治疗以及早期发现和预防方面具有优势。这篇社论文章的中心目的是强调肿瘤微环境对成功的癌症治疗的重要性。
In recent years, huge investigations on cancer progression and invasion have led to understand the pivotal role of tumor microenvironment. The current era of cancer therapy is based on the concept of simply targeting precise mechanisms to kill or to suppress the growth and expansion of malignant cells. Clinical data clearly correlate with in-vitro results, emphasizing the direct impact of cancer environment on disease progression. This provides the opportunity to advance cancer therapy by virtue of targeting cancerous cells and non-cancerous component of tumor in a combinatorial manner. This tailor-made strategy demands the profound knowledge of cross talk between the bio-factors of tumor environment and corresponding pharmacology of drug candidates. The neighborhood of tumor is critical for how cancer cells grow and invade surrounding tissues. It appears that the tumor microenvironment as a "co-op" includes malignant cells, blood vessels, immune/inflammatory factors and extracellular matrix. As a longstanding dilemma, it is well-proved that immune system plays a direct role in the existence and progression of such coop. In some cases, immune cells e.g. tumor associated macrophages (TAMs) infiltrate into tumor and instead of fighting cancer cells, support them to grow. As an important fact, this tumor complexity should not be taken as granted where it can be advantageous in cancer therapy as well as early detection and prevention. The central aim of this editorial article is to highlight the importance of tumor microenvironment for successful cancer therapy.