Molecular signatures database (MSigDB) 3.0

Molecular signatures database (MSigDB) 3.0
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DOI:
10.1093/bioinformatics/btr260
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发表时间:
2011-06-15
期刊:
影响因子:
5.8
通讯作者:
Mesirov, Jill P.
Mesirov, Jill P.
中科院分区:
生物学3区
文献类型:
--
作者:
Liberzon, Arthur;Subramanian, Aravind;Mesirov, Jill P.

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动机:注释良好的基因集代表宇宙的生物过程是至关重要的大规模基因组数据的有意义的和有见地的解释。分子签名数据库(MSigDB)是最广泛使用的存储库之一,这样sets.Results:我们报告的数据库,MSigDB 3.0,超过6700个基因集,一个完整的修订收集的典型途径和实验签名的出版物,增强注释和升级到网站的新版本的可用性。
Motivation: Well-annotated gene sets representing the universe of the biological processes are critical for meaningful and insightful interpretation of large-scale genomic data. The Molecular Signatures Database (MSigDB) is one of the most widely used repositories of such sets.Results: We report the availability of a new version of the database, MSigDB 3.0, with over 6700 gene sets, a complete revision of the collection of canonical pathways and experimental signatures from publications, enhanced annotations and upgrades to the web site.