Clinical Significance and Prognosis Value of Wnt Signaling Pathway in Cervical Cancer
Clinical Significance and Prognosis Value of Wnt Signaling Pathway in Cervical Cancer
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DOI：
10.1002/jcb.25992
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发表时间：
2017-10-01
影响因子：
4
通讯作者：
Avan, Amir
中科院分区：
文献类型：
--
作者：
Bahrami, Afsane;Hasanzadeh, Malihe;Avan, Amir
宫颈癌是女性中最常诊断的癌症之一，支持鉴定新的预后和预测性生物标志物以预测这种恶性肿瘤发展的风险或预测患者预后的需要。在此背景下，无翅型（Wnt）/β-连环蛋白通路的激活被认为是主要的失调通路，其参与宫颈癌发生的多步骤过程，表明其作为潜在的生物标志物或治疗靶点的价值。现就WNT通路在宫颈癌和非肿瘤组织中的差异表达及其作为危险分层和预测宫颈癌患者预后的生物标志物的应用前景作一综述。(C)2017年威利期刊公司
Cervical cancer is among the most commonly diagnosed cancer in women, supporting the need for identification of novel prognostic and predictive biomarkers to predict the risk of developing of this malignancy or predict the prognosis of patients. Against this background, the activation of the Wingless-type (Wnt)/beta-catenin pathway has been suggested as the main dysregulated pathways, which is involved in the multistep process of cervical carcinogenesis, suggesting its value as a potential biomarker or therapeutic target. The aimof current review is to give an overview about the potential application of WNT pathway and its value which is differentially expressed in cervical cancer versus non-tumorigenic tissue as biomarker for risk stratification and predict the prognosis of patients with cervical cancer. (C) 2017 Wiley Periodicals, Inc.