Behavioral and electrophysiological analysis of Ca-activated K-channel transgenes in Drosophila
Behavioral and electrophysiological analysis of Ca-activated K-channel transgenes in Drosophila
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DOI：
10.1111/j.1749-6632.1998.tb09057.x
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发表时间：
1998-01-01
期刊：
影响因子：
--
通讯作者：
Wilbur, JL
中科院分区：
文献类型：
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作者：
Atkinson, NS;Brenner, R;Wilbur, JL
黑腹果蝇的slowpoke基因编码钙激活的IC通道。该基因在神经元、肌肉、气管细胞以及中肠的铜细胞和铁细胞中表达。该基因使用组织特异性转录启动子和选择性mRNA剪接产生大量替代产物，我们已经深入描述了转录是如何调节的，现在正在对不同剪接变体的组织特异性进行编目。据信，产品的多样性有助于使通道属性适应特定组织的需要。电生理和行为分析表明，至少有一些这些产品产生不同的属性通道。
The slowpoke gene of Drosophila melanogaster encodes a Ca-activated IC channel. This gene is expressed in neurons, muscles, tracheal cells, and the copper and iron cells of the midgut. The gene produces a large number of alternative products using tissue-specific transcriptional promoters and alternative mRNA splicing, We have described in great depth how transcription is regulated and are now cataloging the tissue-specificity of different splice variants. It is believed that the diversity of products serves to tailor channel attributes to the needs of specific tissues. Electrophysiological and behavioral assays indicate that at least some of these products produce channels with distinct properties.