The use of OCT in good visual acuity MOGAD and AQP4-NMOSD patients; with and without optic neuritis.
The use of OCT in good visual acuity MOGAD and AQP4-NMOSD patients; with and without optic neuritis.
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DOI：
10.1177/20552173211066446
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发表时间：
2021-10
影响因子：
--
通讯作者：
Palace J
中科院分区：
文献类型：
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作者：
Roca-Fernández A;Camera V;Loncarevic-Whitaker G;Messina S;Mariano R;Vincent A;Sharma S;Leite MI;Palace J
髓磷脂少突胶质细胞抗体相关疾病 (MOGAD) 通常表现为严重的视神经炎 (ON)，但往往比水通道蛋白 4 抗体视神经脊髓炎谱系障碍 (AQP4-NMOSD) 恢复得更好。我们测量了具有良好视觉功能的 MOGAD 和 AQP4-NMOSD 眼睛的 OCT 和 VEP，无论是否患有先前的 ON 发作。令人惊讶的是，在视力良好的 MOGAD-ON 眼和 AQP4-NMOSD-ON 眼中，OCT 和/或 VEP 异常的比例分别为 84% 和 38% (p = 0.009)，而之前没有 ON 的眼睛分别为 18% 和 17%。作为研究的一部分，进行黄斑 OCT 的亚组证实了视力恢复的 MOGAD 眼睛存在视网膜和黄斑缺陷。这些发现对 MOGAD 患者的调查和管理具有重要意义。
Myelin oligodendrocyte-antibody-associated disease (MOGAD) often presents with severe optic neuritis (ON) but tends to recover better than in aquaporin-4 antibody neuromyelitis optica spectrum disorder (AQP4-NMOSD). We measured OCT and VEP in MOGAD and AQP4-NMOSD eyes with good visual function, with or without previous ON episodes. Surprisingly, OCT and/or VEPs were abnormal in 84% MOGAD-ON versus 38% AQP4-NMOSD-ON eyes (p = 0.009) with good vision, compared with 18% and 17% respectively of eyes with no previous ON. A sub-group with macular OCT performed as part of a research study confirmed both retinal and macular defects in visually-recovered MOGAD eyes. These findings have implications for investigation and management of MOGAD patients.