Development of dietary obesity in rats: influence of amount and composition of dietary fat.
Development of dietary obesity in rats: influence of amount and composition of dietary fat.
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发表时间：
1992-05
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通讯作者：
J. Hill;D. Lin;F. Yakubu;J. Peters
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作者：
J. Hill;D. Lin;F. Yakubu;J. Peters
本研究旨在研究膳食脂肪的数量和类型对体重和身体成分的长期影响。成年雄性Wistar大鼠喂食高脂肪（HF; 60%的热量）或低脂肪（LF; 20%的热量）饮食28周。在每种条件下，一半的大鼠接受含饱和脂肪（猪油）的饮食（S），其余的接受含多不饱和脂肪（玉米油）的饮食（U）。从28-39周开始，HF大鼠转换为LF饮食（脂肪类型保持不变）。从40-50周开始，将先前HF喂养的大鼠与LF喂养组中的大鼠体重匹配。HF大鼠在1-28周期间变得比LF大鼠更胖，并且从28-39周保持更重和更胖。在第1-28周期间，膳食脂肪类型对HF或LF大鼠的总体脂没有影响，但在第2阶段（28-39周），U大鼠比S大鼠更重更胖。有一些迹象表明，U饮食与皮下脂肪组织库中脂肪的积累比S饮食更大。从40-50周开始，先前喂食HF饮食的大鼠比LF饮食大鼠需要更少的食物来维持体重。总之，这些结果表明，虽然膳食脂肪的量和类型都可以影响体重和身体组成，但脂肪类型的影响小于膳食脂肪量的影响。
This study was conducted to examine long-term effects of amount and type of dietary fat on body weight and body composition. Adult male Wistar rats were fed high fat (HF; 60% of calories) or low fat (LF; 20% of calories) diets for 28 weeks. Half of the rats in each condition received diets with saturated fat (lard) (S) and the remainder received diets with polyunsaturated fat (corn oil) (U). From 28-39 weeks, HF rats were switched to LF diets (fat type remained constant). From 40-50 weeks, previously HF fed rats were weight-matched to rats in the LF fed groups. HF rats became fatter than LF rats during weeks 1-28 and remained heavier and fatter from weeks 28-39. During weeks 1-28, type of dietary fat had no effect on total body fat in either HF or LF rats, but during period 2 (weeks 28-39), U rats were heavier and fatter than S rats. There was some indication that U diets were associated with greater accumulation of fat in subcutaneous adipose tissue depots than S diets. From 40-50 weeks, rats previously fed the HF diet required less food to maintain their body weight than did LF diet rats. In summary, these results suggest that although both amount and type of dietary fat can affect body weight and body composition, the effects of the type of fat are less than those of amount of dietary fat.