Renal function in the elimination of oral melphalan in patients with multiple myeloma
Renal function in the elimination of oral melphalan in patients with multiple myeloma
复制标题
多发性骨髓瘤患者口服美法仑消除中的肾功能
DOI：
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发表时间：
2004
影响因子：
3
通讯作者：
Z. Desai
中科院分区：
文献类型：
--
作者：
C. G. Adair;J. Bridges;Z. Desai
对11例多发性骨髓瘤患者在化疗第一天和最后一天进行了药代动力学研究。该药物以每天6-14 mg的单次剂量PO给药。通过高效液相色谱法测定美法仑浓度。观察到其他作者注意到的药代动力学参数的患者间变异性。回归分析显示，马法兰的消除速率常数与肾功能呈显著正相关（P=0.003）。描述美法仑总消除速率常数的直线形式由以下公式给出：Kel=5.67×10-3+[4.90×10-5xGFR]。血浆美法仑浓度/时间曲线下面积与肾功能呈显著负相关（P=0.006）。37°C下血浆中美法仑的体外稳定性研究和药代动力学数据表明，水解和肾清除是美法仑消除的主要机制。这项工作定量显示了肾功能和药物消除之间的关系，以及如何使用这些数据来预测美法仑的肌酐清除率半衰期。
SummaryPharmacokinetic studies in 11 patients with multiple myeloma were undertaken on the first and last days of one course of chemotherapy. The drug was administered PO in single doses of 6–14 mg daily. Melphalan concentrations were determined by high-performance liquid chromatography. The interpatient variability of pharmacokinetic parameters noted by other authors was observed. Regression analysis showed a significant positive correlation between the elimination rate constant for melphalan and renal function (P=0.003). The form of the line which describes the overall elimination rate constant for melphalan is given by the equation: Kel=5.67×10-3+[4.90×10-5xGFR]. There was also a significant negative correlation between renal function and the area under the plasma melphalan concentration/time curve (P=0.006). In vitro stability studies of melphalan in plasma at 37°C and pharmacokinetic data suggest that hydrolysis and renal clearance are the major mechanisms of melphalan elimination. This work shows quantitatively the relationship between renal function and drug elimination and how the data may be used in predicting melphalan half-life from creatinine clearance.
犬肾功能不全对马法兰的处置和骨髓毒性的影响。
影响因子：
8.8
作者：
Alberts,DS;Chen,HG;Benz,D;Mason,NL
通讯作者：
Mason,NL
肾功能衰竭对马法兰的骨髓抑制作用的影响：癌症和白血病 B 组经验。
DOI：
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发表时间：
1982
期刊：
Cancer treatment reports
影响因子：
--
作者：
Cornwell3rd,GG;Pajak,TF;McIntyre,OR;Kochwa,S;Dosik,H
通讯作者：
Dosik,H
苯丁酸氮芥和美法仑在人体中的药代动力学比较。
DOI：
10.1007/978-3-642-81488-4_16
发表时间：
1980
期刊：
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer
影响因子：
--
作者：
Alberts,DS;Chang,SY;Chen,HS;Larcom,BJ;Evans,TL
通讯作者：
Evans,TL