Enhancing fraction measured using dynamic contrast-enhanced MRI predicts disease-free survival in patients with carcinoma of the cervix.
Enhancing fraction measured using dynamic contrast-enhanced MRI predicts disease-free survival in patients with carcinoma of the cervix.
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DOI：
10.1038/sj.bjc.6605415
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发表时间：
2010-01-05
影响因子：
8.8
通讯作者：
West, C M L
中科院分区：
文献类型：
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作者：
Donaldson, S B;Buckley, D L;West, C M L
背景技术背景：有必要为简单的成像参数能够预测治疗outcome.METHODS：本回顾性研究分析了50例局部晚期宫颈癌谁接受了动态增强MRI前接受潜在的治愈性放疗。结果：高E（F）肿瘤的无病生存率明显低于低E（F）肿瘤（P=0.011）。解释：E（F）是一种简单的影像学生物标志物，应在多中心环境中进一步研究。
BACKGROUND: There is a need for simple imaging parameters capable of predicting therapeutic outcome.METHODS: This retrospective study analysed 50 patients with locally advanced carcinoma of the cervix who underwent dynamic contrast-enhanced MRI before receiving potentially curative radiotherapy. The proportion of enhancing pixels (E(F)) in the whole-tumour volume post-contrast agent injection was calculated and assessed in relation to disease-free survival (DFS).RESULTS: Tumours with high E(F) had a significantly poorer probability of DFS than those with low E(F) (P=0.011).INTERPRETATION: E(F) is a simple imaging biomarker that should be studied further in a multi-centre setting.