Variational auto-encoding of protein sequences
Variational auto-encoding of protein sequences
复制标题
蛋白质序列的变异自动编码
DOI：
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复制
发表时间：
2017
期刊：
影响因子：
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通讯作者：
M. Nowak
中科院分区：
文献类型：
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作者：
S. Sinai;Eric D. Kelsic;G. Church;M. Nowak
Proteins are responsible for the most diverse set of functions in biology. The ability to extract information from protein sequences and to predict the effects of mutations is extremely valuable in many domains of biology and medicine. However the mapping between protein sequence and function is complex and poorly understood. Here we present an embedding of natural protein sequences using a Variational Auto-Encoder and use it to predict how mutations affect protein function. We use this unsupervised approach to cluster natural variants and learn interactions between sets of positions within a protein. This approach generally performs better than baseline methods that consider no interactions within sequences, and in some cases better than the state-of-the-art approaches that use the inverse-Potts model. This generative model can be used to computationally guide exploration of protein sequence space and to better inform rational and automatic protein design.
深度（呃）学习。
DOI：
10.1523/jneurosci.0153-18.2018
发表时间：
2018
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
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作者：
Srinivasan,Shyam;Greenspan,RalphJ;Stevens,CharlesF;Grover,Dhruv
通讯作者：
Grover,Dhruv