MEASUREMENT OF RADIATION-DOSE TO THE THYROID USING POSITRON EMISSION TOMOGRAPHY
MEASUREMENT OF RADIATION-DOSE TO THE THYROID USING POSITRON EMISSION TOMOGRAPHY
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DOI：
10.1259/0007-1285-60-711-245
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发表时间：
1987-03-01
影响因子：
2.6
通讯作者：
SMITH, A
中科院分区：
文献类型：
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作者：
OTT, RJ;BATTY, V;SMITH, A
使用原型多线正比计数器正电子相机对 22 名接受放射性碘治疗的甲状腺毒症患者的甲状腺组织功能体积进行了测量。生成 124I 在甲状腺中分布的断层扫描图像。发现功能体积在 21-79 cm3 范围内，体积误差为 .+- 量级。 4% 至 .+-. 14%。放射性碘吸收率从 28% 到 98% 不等。使用放射性碘在甲状腺功能亢进症中的有效半衰期为 6 天的值，75 MBq 131I 标准治疗的辐射剂量从 11 到 48 Gy 不等（与推荐的 50-70 Gy 相比）。在五个病例中，PET 成像显示甲状腺中放射性碘的分布不均匀，而传统的针孔闪烁扫描被认为具有均匀的吸收。
Measurements of the functioning volume of thyroid tissue have been made in 22 patients undergoing radioiodine therapy for thyrotoxicosis, using a prototype multiwire proportional counter positron camera. Tomographic images were produced of the distribution of 124I in the thyroid. Functioning volumes were found to be in the range 21-79 cm3 with volume errors of the order of .+-. 4% to .+-. 14%. Radioiodine uptake varied from 28% to 98%. Using a value of 6 days for the effective half-life of radioiodine in hyperactive thyroids, radiation doses from a standard therapy administration of 75 MBq of 131I varied from 11 to 48 Gy (compared with a recommended 50-70 Gy). In five cases PET imaging showed a non-uniform distribution of radioiodine in thyroids thought to have uniform uptake from conventional pinhole scintigraphy.