Dopamine receptors re-explained
Dopamine receptors re-explained
复制标题
重新解释多巴胺受体
DOI：
10.1016/0165-6147(83)90494-7
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发表时间：
1983
影响因子：
13.8
通讯作者：
I. Creese
中科院分区：
文献类型：
--
作者：
S. Leff;I. Creese
多巴胺受体的药理学分类是有争议的。虽然已经提出了多达五个亚类的多巴胺受体，在这篇综述中，我们试图合成，这表明，优势的数据可以包括一个模型，提出只有两个主要类别的多巴胺受体。希望这篇综述能为读者提供一个有用的概念框架，在此框架内评估未来的研究多巴胺能pharmacology.Considerable实验证据，生化和药理学，表明多种类型的多巴胺受体存在于脊椎动物和无脊椎动物的神经和内分泌系统。这些受体的分类可以基于行为、生理、解剖、生物化学和/或生物物理标准。然而，每种分类方法还必须整合药理学标准;即，不同药物如何与每种区别性反应或介导该反应的受体的推定结构亚型相互作用。当然，药理学的最终目标是将有关药物作用的知识整合到上述各个层次的研究中。尽管如此，我们在过去几年中对多巴胺能药理学的研究已经涉及到对识别事件（药物结合）的调查，以及这些事件是如何发生的。
The pharmacological classification of dopamine receptors is controversial. While as many as five subclasses of dopamine receptors have been proposed, in this review we attempt a synthesis which suggests that the preponderance of data can be encompassed by a model proposing only two major classes of dopamine receptors. Hopefully, this review will provide the reader with a useful conceptual framework within which to evaluate future research on dopaminergic pharmacology.Considerable experimental evidence, both biochemical and pharmacological, indicates that multiple classes of dopamine receptors are present in vertebrate and invertebrate nervous and endocrine systems. Classifications of these receptors may be based on behavioral, physiological, anatomical, biochemical and/or biophysical criteria. However, each method of classification must also integrate pharmacological criteria; that is, how diffenmt drugs interact with each discriminating response or putative structural subtype of receptor mediating that response. Of course, the ultimate goal of pharmacology is to integrate knowledge about the action of agents at all the levels of inquiry mentioned above. Nevertheless, our study of dopaminergic pharmacology over the past few years has involved investigations of the recognition event (drug binding) and how such events