Plasma glucose on admission to hospital as a metabolic index of the severity of acute myocardial infarction.
Plasma glucose on admission to hospital as a metabolic index of the severity of acute myocardial infarction.
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入院时血浆葡萄糖作为急性心肌梗死严重程度的代谢指标。
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
Opie Lh
中科院分区：
文献类型：
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作者：
Tansey Mj;Opie Lh
对22例急性心肌梗死12小时内入院的非糖尿病患者进行了一项初步研究，以评估入院时的血糖水平作为梗死面积、发病率和预后的指标。同时还测量了血液游离脂肪酸、胰岛素和钾的浓度。平均酶测梗死面积指数是入院葡萄糖浓度高（大于7.5 mMol/L）患者的3倍（p < 0.005），且入院葡萄糖浓度低（小于7.5 mMol/L）患者的大梗死发生率显著高于入院葡萄糖浓度低（小于7.5 mMol/L）患者（p < 0.05）。前一组患者的平均峰值游离脂肪酸浓度也较高（p < 0.05）。首次梗死后6个月内死亡的患者初始血糖值高于存活时间较长的患者。在非糖尿病患者中，急性心肌梗死症状出现后12小时内测定血浆葡萄糖浓度可用于区分大梗死和小梗死。
: A pilot study was carried out in 22 non-diabetic patients admitted to hospital within 12 hours of acute myocardial infarction to assess the plasma glucose level on admission as an index of infarct size, morbidity and prognosis. Blood free fatty acid, insulin and potassium concentrations were also measured. Mean enzymatically measured infarct size index was three times larger (p less than 0.005) and the incidence of large infarcts was significantly greater (p less than 0.05) in patients with high (greater than 7.5 mMol/L) than in patients with low (less than 7.5 mMol/L) admission glucose concentrations. Patients in the former group also had higher mean peak free fatty acid concentrations (p less than 0.05). Patients who died within six months of their first infarcts had higher initial glucose values than those who survived longer. Plasma glucose concentrations measured within 12 hours of the onset of symptoms of acute myocardial infarction can be used to differentiate those with large from those with small infarcts in non-diabetic patients.