LIPOPROTEIN(A) LEVELS IN THE JAPANESE POPULATION - INFLUENCE OF AGE AND SEX, AND RELATION TO ATHEROSCLEROTIC RISK-FACTORS - THE JICHI-MEDICAL-SCHOOL COHORT STUDY
LIPOPROTEIN(A) LEVELS IN THE JAPANESE POPULATION - INFLUENCE OF AGE AND SEX, AND RELATION TO ATHEROSCLEROTIC RISK-FACTORS - THE JICHI-MEDICAL-SCHOOL COHORT STUDY
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DOI：
10.1093/oxfordjournals.aje.a117516
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发表时间：
1995-05-01
影响因子：
5
通讯作者：
IGARASHI, M
中科院分区：
文献类型：
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作者：
NAGO, N;KAYABA, K;IGARASHI, M
作者研究了 1992 年至 1993 年间大量日本人口中脂蛋白 (a) (Lp(a)) 水平的分布情况以及年龄酸性别分层，以及 Lp(a) 与动脉粥样硬化危险因素之间的关系。受试者为 30 岁以上的 1,235 名男性和 1,762 名女性。采用酶联免疫吸附法测定Lp(a)，女性Lp(a)水平高于男性，Lp(a)随年龄的增加有统计学意义，且Lp(a)水平>30 mg/dl的受试者比例也随年龄增加而增加。在肥胖受试者（体重指数 (BMI) (kg/m(2)) >26）中，Lp(a) 水平低于非肥胖受试者（BMI 小于或等于 26）（男性 p < 0.01；女性 p < 0.05）。男性饮酒者的 Lp(a) 水平低于不饮酒者 (p < 0.05)。年龄、低密度脂蛋白减去 Lp(a) 胆固醇 [Lp(a) x 0.3] 和纤维蛋白原水平在男女中均与 Lp(a) 呈正相关，饮酒量（g/天）和甘油三酯在男性中与 Lp(a) 呈负相关，而总胆固醇减去 Lp(a) 胆固醇 [Lp(a) x 0.3]、高密度脂蛋白和因子 VII 在男性中呈正相关。女性。多元逻辑回归分析显示，男性的甘油三酯和女性的BMI和纤维蛋白原是显着的自变量。作者得出结论，Lp(a) 水平受多种因素影响，如饮酒、BMI、性别和年龄，并且不仅与血脂水平相关，还与纤维蛋白原和因子 VII 等止血因素相关。
The authors studied the distribution of lipoprotein(a) (Lp(a)) levels with stratification for age acid sex, as well as the relation between Lp(a) and atherosclerotic risk factors in a large Japanese population between 1992 and 1993. The subjects were 1,235 males and 1,762 females over 30 years old. Lp(a) was measured by an enzyme-linked immunosorbent assay, Lp(a) levels were higher in females than in males, The increase in Lp(a) with age was statistically significant, and the proportion of subjects with Lp(a) levels >30 mg/dl also increased with age. In the obese subjects (body mass index (BMI) (kg/m(2)) >26), Lp(a) levels were lower than in the non-obese subjects (BMI less than or equal to 26) (p < 0.01 in males; p < 0.05 in females). Male alcohol drinkers had lower Lp(a) levels than nondrinkers (p < 0.05). Age, low density lipoprotein subtracting Lp(a) cholesterol [Lp(a) x 0.3], and fibrinogen level were all positively correlated with Lp(a) in both sexes, Alcohol consumption (g/day) and triglycerides were inversely correlated with Lp(a) in males, while total cholesterol subtracting Lp(a) cholesterol [Lp(a) x 0.3], high density lipoprotein, and factor VII were positively correlated in females. Multiple logistic regression analysis showed that triglycerides in males and BMI and fibrinogen in females were significant independent variables. The authors conclude that Lp(a) level is affected by various factors, such as alcohol drinking, BMI, sex, and age, and is not only correlated with lipid levels but also with hemostatic factors such as fibrinogen and factor VII.