Effect of intravenous immunoglobulin G on neutrophil kinetics during experimental group B streptococcal infection in neonatal rats.
Effect of intravenous immunoglobulin G on neutrophil kinetics during experimental group B streptococcal infection in neonatal rats.
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静脉注射免疫球蛋白 G 对实验 B 组链球菌感染新生大鼠中性粒细胞动力学的影响。
DOI：
10.1093/clinids/8.supplement_4.s401
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Hill,HR
中科院分区：
文献类型：
--
作者：
Harper,TE;Christensen,RD;Rothstein,G;Hill,HR
测试了改良形式的血清免疫球蛋白 G (pH 4.25) 对患有 III 型、B 组链球菌肺炎和败血症的新生大鼠中性粒细胞动力学和存活率的影响。 30只动物每只接受105个微生物/克体重的经胸接种； 48小时内全部死亡。当细菌接种时腹腔内给予100、1,000或2,000 mg免疫球蛋白G/kg时，存活率分别升至20%、90%和100%。即使在经胸接种细菌2小时后腹膜内施用免疫球蛋白制剂，所有19只动物仍存活。当免疫球蛋白施用延迟22小时时，15只动物中仅7只存活。免疫球蛋白促进中性粒细胞炎症反应：当施用免疫球蛋白（而不是白蛋白对照）时，中性粒细胞从储存池中更快地释放，并在细菌接种部位更快地积累。与受感染的对照动物不同，免疫球蛋白接受者没有出现中性粒细胞减少症或中性粒细胞储存池的耗尽。
A modified form of serum immunoglobulin G (pH 4.25) was tested for its effect on neutrophil kinetics and survival rates in neonatal rats with type III, group B streptococcal pneumonia and sepsis. Each of 30 animals received a transthoracic inoculation of 105organisms/g of body weight; all died within 48 hr. When 100, 1,000, or 2,000 mg of immunoglobulin G/kg was administered intraperitonally at the time of bacterial inoculation, survival rates rose to 20%, 90%, and 100%,respectively. Evenwhen the immunoglobulin preparation was administered intraperitoneally 2 hr after transthoracic inoculation of bacteria, all 19 animals survived.Only sevenof 15 animals survived when immunoglobulin administration was delayed for 22 hr. Immunoglobulin facilitated the neutrophil inflammatory response: when immunoglobulin (rather than an albumin control) was administered, neutrophils werereleased more rapidly from the storage pool and accumulated more quickly at the site of bacterial inoculation. Unlike infected control animals, immunoglobulin recipients did not develop neutropenia or depletion of the neutrophil storage pool.