Quantifying the buildup in extent and complexity of free exploration in mice
Quantifying the buildup in extent and complexity of free exploration in mice
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DOI：
10.1073/pnas.1014837108
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发表时间：
2011-09-13
影响因子：
11.1
通讯作者：
Golani, Ilan
中科院分区：
文献类型：
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作者：
Benjamini, Yoav;Fonio, Ehud;Golani, Ilan
为了了解动物自身的功能世界，我们在允许动物调节其行为增长率的情况下研究其行为，并为我们提供量化其每时每刻的发育动态的机会。因此，我们能够证明小鼠的探索行为由重复运动的序列组成：范围和复杂性增加的迭代过程，其假定的功能是对在探索新环境期间获得的输入进行系统的主动管理。我们利用这项研究来展示我们量化行为的方法：针对动物主动管理的行为方面，并使用跨菌株和治疗具有区别性并可在实验室复制的措施。
To obtain a perspective on an animal's own functional world, we study its behavior in situations that allow the animal to regulate the growth rate of its behavior and provide us with the opportunity to quantify its moment-by-moment developmental dynamics. Thus, we are able to show that mouse exploratory behavior consists of sequences of repeated motion: iterative processes that increase in extent and complexity, whose presumed function is a systematic active management of input acquired during the exploration of a novel environment. We use this study to demonstrate our approach to quantifying behavior: targeting aspects of behavior that are shown to be actively managed by the animal, and using measures that are discriminative across strains and treatments and replicable across laboratories.