Osteogenicity of biphasic calcium phosphate ceramics and bone autograft in a goat model
Osteogenicity of biphasic calcium phosphate ceramics and bone autograft in a goat model
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DOI：
10.1016/j.biomaterials.2007.11.034
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发表时间：
2008-03-01
期刊：
影响因子：
14
通讯作者：
Layrolle, Pierre
中科院分区：
文献类型：
--
作者：
Fellah, Borhane H.;Gauthier, Olivier;Layrolle, Pierre
这项工作的目的是比较磷酸钙陶瓷颗粒与异位和原位自体骨移植物的成骨性。由羟基磷灰石（HA）和β-磷酸三钙（β-TCP）以60/40的比例组成的双相磷酸钙（BCP）颗粒在1050、1125和1200 ℃下烧结，产生不同的微孔。将BCP陶瓷颗粒或自体骨片（n = 7）植入椎旁肌中。在异位部位6周或12周后，在BCP植入物或自体骨片中均未观察到骨诱导。中空和钻孔的聚四氟乙烯（PTFE）圆柱体填充自体骨，BCP颗粒或空着，然后植入到股骨骨骺的临界尺寸缺损中。空的PTFE圆柱体含有骨髓和血管，但没有矿化骨，表明该模型阻止骨长入（12周时为0.56 - 0.43%）。6周后，在股骨部位观察到与BCP 1050和BCP 1125颗粒接触的骨形成。BCP 1050和BCPI 125 12周后的骨量分别为5.6 +/-17.3和9.6 +/-6.6%。BCP 1200种植体观察到的骨形成非常少（12周时为1.5 +/-1.3%）。在异位和原位部位，自体骨碎片均被彻底吸收（从最初的19.4 +/-3.7%到12周时的1.7 +/-1.2%）。这项研究表明，在临界尺寸的骨缺损中，合成骨替代物可能比自体骨移植物具有更好的稳定性和成骨特性。(C)2007爱思唯尔有限公司保留所有权利。
The aim of this work was to compare the osteogenicity of calcium phosphate ceramic granules with autologous bone graft in ectopic and orthotopic sites. Biphasic calcium phosphate (BCP) granules composed of hydroxyapatite (HA) and beta-tricalcium phosphate (beta-TCP) in a 60/40 ratio were sintered at 1050, 1125 and 1200 degrees C, producing different microporosities. Either BCP ceramic granules or autologous bone chips (n = 7) were implanted into paraspinal muscles. Osteoinduction was not observed in either the BCP implants or autologous bone chips after 6 or 12 weeks in the ectopic sites. Hollow and bored polytetrafluoroethylene (PTFE) cylinders were filled with autologous bone, BCP granules or left empty, then implanted into critical-sized defects in femoral epiphyses. The PTFE cylinders left empty contained marrow and blood vessels but not mineralized bone, indicating that this model prevented bone ingrowth (0.56 0.43% at 12 weeks). Bone formation was observed in contact with the BCP1050 and BCP1125 granules in the femoral sites after 6 weeks. The amount of bone after 12 weeks was 5.6 +/- 17.3 and 9.6 +/- 6.6% for BCP1050 and BCPI 125, respectively. Very little bone formation was observed with the BCP1200 implants (1.5 +/- 1.3% at 12 weeks). In both the ectopic and orthotopic sites, autologous bone chips were drastically resorbed (from 19.4 +/- 3.7% initially to 1.7 +/- 1.2% at 12 weeks). This study shows that synthetic bone substitutes may have superior stability and osteogenic properties than autologous bone grafts in critical-sized bone defects. (C) 2007 Elsevier Ltd. All rights reserved.