Longitudinal study of seroprevalence and serostability of the human polyomaviruses JCV and BKV in organ transplant recipients
Longitudinal study of seroprevalence and serostability of the human polyomaviruses JCV and BKV in organ transplant recipients
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DOI：
10.1002/jmv.23472
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发表时间：
2013-02-01
影响因子：
12.7
通讯作者：
Waterboer, Tim
中科院分区：
文献类型：
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作者：
Antonsson, Annika;Pawlita, Michael;Waterboer, Tim
人类多瘤病毒BKV和JCV主要在儿童期引起亚临床感染。器官移植后的系统性免疫抑制可导致持续性多瘤病毒感染的再激活，这可引起移植器官的排斥反应。在441例欧洲实体器官移植受者中测定了BKV和JCV血清阳性率和血清稳定性。在移植后平均24天收集基线样品，然后在18个月的随访期内在多达6个不同的时间点收集血清。基线时BKV的总体血清阳性率为97%，随时间变化很小。基线时JCV的患病率为76%，随访结束时增加至80%。BKV血清阳性率最高的年龄组（100%），并随着年龄的增加而下降（92%，在最大的年龄组; P？
The human polyomaviruses BKV and JCV cause mostly subclinical infections in childhood. Systemical immunosuppression after organ transplantation can lead to reactivation of persistent polyomavirus infections which may cause rejection of the transplanted organ. BKV and JCV seroprevalence and serostability was measured in 441 European solid organ transplanted recipients. Baseline samples were collected on average 24 days post-transplantation and sera were then collected over an 18 months follow-up period on up to six different time points. The overall seroprevalence at baseline for BKV was 97% with very little change over time. Prevalence for JCV was 76% at baseline and increased to 80% at the end of follow-up. BKV seroprevalence was highest in the youngest age group (100%) and decreased with increasing age (92% in the oldest age group; P?