Significance of hyperglycaemia in first trimester pregnancy (SHIFT): A pilot study and literature review
Significance of hyperglycaemia in first trimester pregnancy (SHIFT): A pilot study and literature review
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DOI：
10.1111/ajo.13254
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发表时间：
2020-09-16
影响因子：
1.7
通讯作者：
Wynne, Katie
中科院分区：
文献类型：
--
作者：
Kuehn, Johanna;Gebuehr, Alison;Wynne, Katie
国际指南建议在怀孕早期筛查显性糖尿病。妊娠早期空腹血糖（FPG）水平可在妊娠后期诊断为妊娠期糖尿病（GDM）的妇女正在被识别和治疗，尽管其风险和益处不确定。目前的诊断标准和管理建议在早期妊娠期糖尿病的证据进行审查。一项前瞻性观察性研究的结果评估了妊娠早期轻度空腹高血糖症女性向GDM的进展和预先规定的母胎结局，结果表明，FPG 5.1-5.6 mmol/L的女性可能需要在妊娠早期进行积极管理。
International guidelines recommend screening for overt diabetes in early pregnancy. Women in their first trimester with fasting plasma glucose (FPG) levels that would be diagnostic of gestational diabetes mellitus (GDM) in later pregnancy are being identified and treated despite uncertainty regarding the risks and benefits. The evidence for the current diagnostic criteria and management recommendations in early GDM are reviewed. The results of a prospective observational study assessing the progression to GDM and prespecified maternal-fetal outcomes in women with mild fasting hyperglycaemia in the first trimester suggest that women with FPG 5.1-5.6 mmol/L may warrant proactive management in early pregnancy.