Chloramphenicol resistance in vancomycin-resistant enterococcal bacteremia: Impact of priop fluoroquinolone use?
Chloramphenicol resistance in vancomycin-resistant enterococcal bacteremia: Impact of priop fluoroquinolone use?
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DOI：
10.1086/502365
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发表时间：
2004-02-01
影响因子：
4.5
通讯作者：
Lautenbach, E
中科院分区：
文献类型：
--
作者：
Gould, CV;Fishman, NO;Lautenbach, E
目的：近十年来，万古霉素耐药肠球菌(VRE)的流行率显著上升。关于VRE对氯霉素耐药的流行病学资料很少。设计：调查和病例对照研究。设置：一个有725个床位的三级保健学术医学中心和一个有344个床位的城市社区医院。研究对象：血液培养证实VRE的住院患者。方法：我们调查了1991-2002年VRE血液分离株中氯霉素耐药性的流行趋势，并进行了病例对照研究，以确定这些分离株对氯霉素耐药的危险因素。结果：从1991年到2002年，VRE对氯霉素耐药的年流行率从0%上升到12%(P
OBJECTIVE: The prevalence of vancomycin-resistant enterococci (VRE) has increased markedly during the past decade. Few data exist regarding the epidemiology of resistance of VRE to chloramphenicol, one of the few therapeutic options.DESIGN: Survey and case-control study.SETTING: A 725-bed, tertiary-care academic medical center and a 344-bed urban community hospital.PATIENTS: Hospitalized patients with blood cultures demonstrating VRE.METHODS: We examined the trends in the prevalence of chloramphenicol resistance in VRE blood isolates at our institution from 1991 through 2002 and conducted a case-control study to identify risk factors for chloramphenicol resistance among these isolates.RESULTS: From 1991 through 2002, the annual prevalence of chloramphenicol-resistant VRE increased from 0% to 12% (P